The dynamic interactive neurocognitive systems underpinning language and semantic cognition, and their disorders.

支持语言和语义认知的动态交互式神经认知系统及其疾病。

• 批准号: MC_UU_00030/9
• 负责人: Matthew Lambon Ralph
• 金额: $ 350.79万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00030%2F9
• 关键词: dynamic; interactive; neurocognitive; systems; underpinning

Language is a fundamental ability that is core to almost every aspect of our personal, social and professional lives. Consequently, when language is compromised, people can have severe disabilities. Language impairments are common across multiple types of acute and chronic brain damage including stroke, multiple types and subtypes of dementia, acute neurological diseases, etc. The core goals of our long-term neuroscience research programme, therefore, are to (i) understand the processes, computations and brain mechanisms that support healthy language function; (ii) investigate the nature of language disorders across different types of brain disease; and (iii) explore how these process partially recovery after brain damage, why this recovery varies across people and the bases of language rehabilitation. Our research programme will use a variety of methods and techniques to explore function in healthy people and in patients. These methods include brain imaging, brain stimulation, computer based models and advanced mathematical analysis techniques. Our target in some of the new work is to understand how the mind can be flexible and efficient in normal operation, how it responds to brain damage and, in turn, how to maximise patients’ recovery.

语言是一种基本能力，几乎是我们个人、社会和职业生活各个方面的核心。因此，当语言受到损害时，人们可能会有严重的残疾。语言障碍在多种类型的急性和慢性脑损伤中都很常见，包括中风、多种类型和亚型的痴呆、急性神经系统疾病等。因此，我们长期神经科学研究计划的核心目标是：(I)了解支持健康语言功能的过程、计算和大脑机制；(Ii)调查不同类型大脑疾病的语言障碍的性质；以及(Iii)探讨这些过程是如何在脑损伤后部分恢复的，为什么不同的人和语言康复的基础不同。我们的研究计划将使用各种方法和技术来探索健康人和患者的功能。这些方法包括脑成像、脑刺激、基于计算机的模型和高级数学分析技术。我们在一些新工作中的目标是了解大脑如何在正常操作中灵活和高效，它如何应对大脑损伤，进而了解如何最大限度地促进患者的康复。

项目成果

An efficient, accurate and clinically-applicable index of content word fluency in Aphasia.

• DOI: 10.1080/02687038.2021.1923946
• 发表时间: 2022-08-03
• 期刊: Aphasiology
• 影响因子: 2
• 作者: Alyahya RSW;Conroy P;Halai AD;Ralph MAL
• 通讯作者: Ralph MAL

A middle ground where executive control meets semantics: the neural substrates of semantic control are topographically sandwiched between the multiple-demand and default-mode systems.

• DOI: 10.1093/cercor/bhac358
• 发表时间: 2023-04-04
• 期刊: Cerebral cortex (New York, N.Y. : 1991)

The cognitive and neural underpinnings of discourse coherence in post-stroke aphasia.

• DOI: 10.1093/braincomms/fcac147
• 发表时间: 2022
• 期刊: Brain communications
• 影响因子: 4.8

The neurocognitive cornerstones of creative thought

创造性思维的神经认知基石

• DOI: 10.31234/osf.io/mv2q7
• 发表时间: 2023
• 作者: Chan M

The Role of the Posterior Medial Network in Language Comprehension: Dissociating Construction of Episodic versus Semantic Representations

后内侧网络在语言理解中的作用：情景表征与语义表征的分离构建

• DOI: 10.1101/2022.09.03.506471
• 发表时间: 2022
• 作者: Branzi F