A formal group theory-based model in primates for studying interactive social behavior and its dysfunction

用于研究互动社会行为及其功能障碍的基于正式群体理论的灵长类动物模型

• 批准号: 10567456
• 负责人: Ziv Williams
• 金额: $ 50.05万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10567456
• 关键词: Affect; Alcoholism; Amygdaloid structure; Animal Model; Animals; Anterior; Area; Behavior; Code; Cues; Dimensions; Disease; Dissociation; Dorsal; Ecology; Elements; Facial Expression; Functional disorder; Future; Human; Individual; Intervention; Investigation; Joints; Learning; Macaca mulatta; Major Depressive Disorder; Modeling; Neurology; Neurons; Neurosciences; Outcome; Paint; Parietal; Play; Population; Primates; Psychology; Role; Schizophrenia; Site; Social Behavior; Social Environment; Social Interaction; Specificity; Structure; Techniques; Testing; Time; Time Study; autism spectrum disorder; base; cingulate cortex; experience; experimental study; field study; gaze; member; neural; neurocognitive disorder; neuromechanism; neuroregulation; psychosocial; response; social; social cognition; social group; theories; time use

A formal group theory-based model in primates for studying interactive social behavior and its dysfunction Unlike most forms of solitary behavior that have been broadly studied through animal models, remarkably little is known about the single-neuronal or causal bases of interactive social behavior and its dysfunction. One of the major reasons for this limitation is the general lack of animal models and framework for studying the neural substrates of social behavior whereby two or more individuals interact in real-time and in a way that is amenable to neuronal analysis or perturbation techniques. This limited understanding impacts not only wide spanning fields of study such as ecology, neurology and psychology but also our ability to treat conditions such as autism-spectrum disorder in which social behavior is prominently affected. Primates are highly social animals that share many behaviors in common with humans and can serve as a potential model for understanding the basic elements that underlie interactive behavior. In this proposal, we aim to build on our team’s unique combined experience with jointly interacting primate pairs and groups, social theory, multi-site neuronal recordings and time-resolved neuromodulation techniques to begin identifying some of the basic neuronal encoding components of interactive behaviors, their representation within and across cortical populations, and their dynamic across short and long temporal scales. Using social group theory in primates together with population modeling and perturbation techniques, we will investigate core social constructs such as agency identity, group dynamics and decision strategies essential for effective social behavior. We will also test specific hypotheses on the causal contribution that distinct frontal, temporal and parietal areas play in social interaction and what exact aspects are involved. Taken together, this proposal aims to provide a formal theory- based model by which to begin investigating interactive social behavior at the single-neuronal, population and circuit-based levels. We believe that this is an essential new line of investigation and has the potential to open up a poorly explored but important field within neuroscience and from which to begin testing neuro-modulatory interventions aimed at treating psychosocial disorders.

一个正式的基于群体理论的灵长类动物互动社会研究模型 行为及其功能障碍 与大多数通过动物模型广泛研究的孤独行为不同， 关于互动社会行为及其功能障碍的单神经元或因果基础是已知的。之一 这种限制的主要原因是普遍缺乏研究神经系统的动物模型和框架。 两个或多个人实时互动的社会行为的基础， 适用于神经元分析或扰动技术。这种有限的理解不仅影响广泛 跨越生态学、神经学和心理学等研究领域， 自闭症是一种社交行为受到显著影响的疾病。灵长类动物是高度社会化的 动物与人类有许多共同的行为，可以作为一个潜在的模型， 理解互动行为的基本要素。在这项建议中，我们的目标是建立在我们的 团队的独特经验与共同互动的灵长类动物对和群体，社会理论，多站点 神经元记录和时间分辨神经调节技术，开始确定一些基本的 交互行为的神经元编码成分，它们在皮层内和皮层间的表达 人口，以及它们在短期和长期时间尺度上的动态。在灵长类动物中运用社会群体理论 与人口建模和扰动技术一起，我们将研究核心社会结构， 作为机构身份，群体动态和决策策略，对有效的社会行为至关重要。我们还将 测试特定假设的因果关系的贡献，不同的额叶，颞叶和顶叶地区发挥社会 具体涉及哪些方面。总的来说，这个建议旨在提供一个正式的理论- 基于模型，通过该模型开始研究单神经元群体的交互式社会行为， 基于电路的水平。我们认为，这是一个重要的新的调查路线，并有可能打开 在神经科学中，这是一个探索不足但很重要的领域，从这个领域开始开始测试神经调节 旨在治疗心理社会障碍的干预措施。