Using game theory in primates to study the distributed neuronal and time-casual underpinnings of interactive social behavior

在灵长类动物中应用博弈论研究分布的神经元和时间- 互动式社会行为的因果基础 尽管联合互动社会行为的重要性及其在许多方面的广泛参与 神经认知障碍，其单神经元基础、群体水平编码和时间原因 支撑因素在很大程度上仍不得而知。这种限制的很大一部分原因是我们无法 在人类身上提出这样的问题。博弈论和迭代囚徒困境(IPD)博弈 特别是，为研究和解开多维的 对交互式社交决策进行编码。在这里，我们将以我们集团最近的创新为基础，通过DUAL 相互作用的灵长类动物对，神经种群记录和脑深部刺激(DBS)，以便 系统地研究互动社会行为的基本神经元构件。在……里面 由我们的团队进行的初步研究，我们已经确定了一些关键的神经元 共同社会决策背后的计算。我们还建立了重要的行为验证 灵长类动物模型的测量、社会背景控制和交叉配对确认。在这项研究中，我们 将首次调查三个主要领域的参与情况，理论上这些领域包括 “社交大脑”对互动社交行为的不同方面进行分布式编码和调节。 这些区域包括背侧前扣带回皮质、顶内前区和基底外侧区。 杏仁核。我们将专门研究自我与他人的单个神经元和群体编码 机构、联合互动、社会背景和代理人身份。我们将测试这些表示如何 受社会线索的调节，并考察标准和 事件触发的DBS。总体而言，这项提议代表了一种全新的调查路线，而不是 可能在人类身上进行，并开辟了神经科学中一个重要的未探索领域。这个 拟议中的一系列研究将为灵长类动物的社会大脑提供首个全面的路线图。 神经元和人群水平，并为未来针对社会性疾病的治疗提供关键指导 行为障碍。

Using game theory in primates to study the distributed neuronal and time- causal underpinnings of interactive social behavior Despite the importance of joint interactive social behavior and its broad involvement in many neurocognitive disorders, its single-neuronal basis, population-level encoding and time-causal underpinnings are still largely unknown. A major part of this limitation has come from our inability to ask such questions in humans. Game theory, and the iterated Prisoner's Dilemma (iPD) game in particular, provides a well-studied platform for investigating and dissociating the multi-dimensional encoding of interactive social decisions. Here, we will build on recent innovations by our group with dual interacting primate-pairs, neural population recording and deep brain stimulation (DBS) in order to systematically investigate the basic neuronal building blocks of interactive social behavior. In preliminary studies performed by our groups, we have already identified some of the key neuronal computations underlying joint social decisions. We have also established important behavioral validation measures, social context controls and cross-pair confirmations for the primate model. In this study, we will investigate, for the first time, the involvement of three principal areas theorized to comprise the “social brain” in distributively encoding and modulating distinct aspects of interactive social behavior. These areas include the dorsal anterior cingulate cortex, anterior intraparietal area and the basolateral amygdala. We will specifically examine the single-neuronal and population encoding of self vs. other agency, joint interaction, social context and agent identity. We will test how these representations are modulated by social cues and examine the targeted modulation of the different areas by both standard and event-triggered DBS. Overall, this proposal represents a completely new line of investigation that is not possible to conduct in humans, and opens up an important unexplored area in neuroscience. The proposed set of studies will provide the first comprehensive roadmap of the primate “social brain” at the neuronal and population level, and offer critical guidance for future targeted treatments of social behavioral disorders.