Using game theory in primates to study the distributed neuronal and time-casual underpinnings of interactive social behavior

在灵长类动物中使用博弈论来研究分布的神经元和时间- 互动社会行为的因果基础 尽管联合互动社会行为的重要性及其在许多领域的广泛参与 神经认知障碍，其单神经元基础，群体水平编码和时间因果关系 基本情况仍然不明。这种限制的主要部分来自于我们无法 在人类身上问这样的问题。博弈论和迭代囚徒困境（iPD）博弈 特别是，提供了一个良好的研究平台，调查和分离的多维 交互式社会决策的编码。在这里，我们将建立在我们集团最近的创新与双重 相互作用的灵长类动物对，神经群体记录和深部脑刺激（DBS），以 系统地研究互动社会行为的基本神经元构建模块。在 通过我们小组的初步研究，我们已经确定了一些关键的神经元 共同社会决策背后的计算。我们还建立了重要的行为验证 措施，社会背景控制和交叉对灵长类动物模型的确认。本研究 将调查，第一次，理论上包括三个主要领域的参与， “社会大脑”在分布式编码和调节互动社会行为的不同方面。 这些区域包括背侧前扣带皮层、前顶内区和基底外侧区 杏仁核我们将特别研究自我与他人的单神经元和群体编码 代理，联合互动，社会背景和代理身份。我们将测试这些表示是如何 调制的社会线索，并检查有针对性的调制的不同领域的标准和 事件触发DBS总的来说，这项建议代表了一个全新的调查路线， 在人类中进行，并开辟了神经科学中一个重要的未探索领域。的 拟议的一系列研究将提供灵长类动物“社会大脑”的第一个全面的路线图， 神经元和群体水平，并为未来有针对性的治疗社会 行为障碍

Using game theory in primates to study the distributed neuronal and time- causal underpinnings of interactive social behavior Despite the importance of joint interactive social behavior and its broad involvement in many neurocognitive disorders, its single-neuronal basis, population-level encoding and time-causal underpinnings are still largely unknown. A major part of this limitation has come from our inability to ask such questions in humans. Game theory, and the iterated Prisoner's Dilemma (iPD) game in particular, provides a well-studied platform for investigating and dissociating the multi-dimensional encoding of interactive social decisions. Here, we will build on recent innovations by our group with dual interacting primate-pairs, neural population recording and deep brain stimulation (DBS) in order to systematically investigate the basic neuronal building blocks of interactive social behavior. In preliminary studies performed by our groups, we have already identified some of the key neuronal computations underlying joint social decisions. We have also established important behavioral validation measures, social context controls and cross-pair confirmations for the primate model. In this study, we will investigate, for the first time, the involvement of three principal areas theorized to comprise the “social brain” in distributively encoding and modulating distinct aspects of interactive social behavior. These areas include the dorsal anterior cingulate cortex, anterior intraparietal area and the basolateral amygdala. We will specifically examine the single-neuronal and population encoding of self vs. other agency, joint interaction, social context and agent identity. We will test how these representations are modulated by social cues and examine the targeted modulation of the different areas by both standard and event-triggered DBS. Overall, this proposal represents a completely new line of investigation that is not possible to conduct in humans, and opens up an important unexplored area in neuroscience. The proposed set of studies will provide the first comprehensive roadmap of the primate “social brain” at the neuronal and population level, and offer critical guidance for future targeted treatments of social behavioral disorders.