Using game theory in primates to study the distributed neuronal and time-casual underpinnings of interactive social behavior

利用灵长类动物的博弈论来研究交互式社交行为的分布式神经元和时间休闲基础

• 批准号: 10197791
• 负责人: Ziv Williams
• 金额: $ 40.98万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10197791
• 关键词: Address; Affect; Alcoholism; Amygdaloid structure; Animal Model; Anterior; Area; Behavior; Behavior Control; Behavior Disorders; Behavioral; Brain; Code; Computational Technique; Cues; Data; Decision Making; Deep Brain Stimulation; Disease; Dorsal; Elements; Event; Facial Expression; Foundations; Functional disorder; Future; Game Theory; Human; Impairment; Individual; Investigation; Joints; Macaca mulatta; Major Depressive Disorder; Measures; Mediating; Modeling; Neurons; Neurosciences; Outcome; Play; Population; Primates; Prisoner' s Dilemma; Rewards; Schizophrenia; Site; Social Behavior; Social Environment; Social Interaction; Structure; Sum; Techniques; Testing; Time; Time Study; Training; Validation; Work; autism spectrum disorder; base; cingulate cortex; experience; gaze; innovation; multimodality; neural circuit; neurocognitive disorder; neuroregulation; relating to nervous system; response; social; time use

Using game theory in primates to study the distributed neuronal and time- causal underpinnings of interactive social behavior Despite the importance of joint interactive social behavior and its broad involvement in many neurocognitive disorders, its single-neuronal basis, population-level encoding and time-causal underpinnings are still largely unknown. A major part of this limitation has come from our inability to ask such questions in humans. Game theory, and the iterated Prisoner's Dilemma (iPD) game in particular, provides a well-studied platform for investigating and dissociating the multi-dimensional encoding of interactive social decisions. Here, we will build on recent innovations by our group with dual interacting primate-pairs, neural population recording and deep brain stimulation (DBS) in order to systematically investigate the basic neuronal building blocks of interactive social behavior. In preliminary studies performed by our groups, we have already identified some of the key neuronal computations underlying joint social decisions. We have also established important behavioral validation measures, social context controls and cross-pair confirmations for the primate model. In this study, we will investigate, for the first time, the involvement of three principal areas theorized to comprise the “social brain” in distributively encoding and modulating distinct aspects of interactive social behavior. These areas include the dorsal anterior cingulate cortex, anterior intraparietal area and the basolateral amygdala. We will specifically examine the single-neuronal and population encoding of self vs. other agency, joint interaction, social context and agent identity. We will test how these representations are modulated by social cues and examine the targeted modulation of the different areas by both standard and event-triggered DBS. Overall, this proposal represents a completely new line of investigation that is not possible to conduct in humans, and opens up an important unexplored area in neuroscience. The proposed set of studies will provide the first comprehensive roadmap of the primate “social brain” at the neuronal and population level, and offer critical guidance for future targeted treatments of social behavioral disorders.

在初级中使用游戏理论来研究分布式神经元和时间 - 互动社会行为的因果关系 尽管联合互动社会行为及其在许多人中的广泛参与很重要 神经认知障碍，单神经元，人口级编码和时间疗程 基础基本上仍然是未知的。这一限制的主要部分是我们无法 在人类中问这样的问题。游戏理论，以及迭代的囚犯困境（IPD）游戏 特别，提供了一个经过良好研究的平台，用于调查和分离多维 互动社会决策的编码。在这里，我们将以双重创新为基础 相互作用的灵长类动物对，神经种群记录和深脑刺激（DB） 系统地研究互动社会行为的基本神经元基础。在 我们的小组进行的初步研究，我们已经确定了一些关键神经元 共同社会决策的基础计算。我们还建立了重要的行为验证 对私人模型的措施，社会环境控制和跨对确认。在这项研究中，我们 将首次调查三个理论上的三个主要领域以完成 分布式编码和调节互动社会行为的不同方面的“社会大脑”。 这些区域包括前扣带回皮层，前室内区域和底部 杏仁核。我们将专门检查自我与其他编码的单神经元和人口 代理，联合互动，社会环境和代理身份。我们将测试这些表示方式 由社会提示调节，并根据标准和 事件触发的DBS。总体而言，该提案代表了一项全新的调查线 可能在人类中进行，并打开神经科学中重要的意外领域。 拟议的一组研究将为灵长类动物“社交大脑”提供第一个全面的路线图 神经元和人口水平，并为未来的社会有针对性治疗提供关键指导 行为障碍。