Data mining epidemiological relationships

数据挖掘流行病学关系

• 批准号: MC_UU_00032/3
• 负责人: Tom Gaunt
• 金额: $ 198.65万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00032%2F3
• 关键词: Data; mining; epidemiological; relationships

We aim to develop and use cutting edge data mining tools to identify risk factors that cause common diseases and potential drug targets that could prevent or treat these diseases. Methods developed within the MRC Integrative Epidemiology Unit use genetic data to help identify lifestyle risk factors that could be modified to reduce the risk or impact of disease, and can also identify potential drug targets. This programme is developing tools and databases to automate this type of analysis and apply it to large-scale population datasets to help us discover new ways to prevent and treat disease. We are also combining the evidence from these analyses with other types of biomedical information in a “knowledge graph” to enable us to investigate the mechanisms underlying disease, identify new targets for treatment or prevention, predict side effects of drugs and identify opportunities to repurpose existing drugs for other diseases. The methods, software and knowledge graph we are developing are made openly available to the research community to maximise their potential to improve population health.

我们的目标是开发和使用尖端的数据挖掘工具，以确定导致常见疾病的风险因素和潜在的药物靶点，可以预防或治疗这些疾病。MRC综合流行病学部门开发的方法使用遗传数据来帮助确定可以修改以降低疾病风险或影响的生活方式风险因素，并且还可以确定潜在的药物靶点。该计划正在开发工具和数据库，以自动进行此类分析，并将其应用于大规模人口数据集，以帮助我们发现预防和治疗疾病的新方法。我们还将这些分析的证据与其他类型的生物医学信息结合在一起，形成一个“知识图谱”，使我们能够研究疾病的潜在机制，确定治疗或预防的新靶点，预测药物的副作用，并确定将现有药物重新用于其他疾病的机会。我们正在开发的方法，软件和知识图谱向研究界开放，以最大限度地发挥其改善人口健康的潜力。

项目成果

Investigating effect modification between childhood maltreatment and genetic risk for cardiovascular disease in the UK Biobank.

在英国生物库中调查儿童虐待与心血管疾病的遗传风险之间的修改。

• DOI: 10.1371/journal.pone.0285258
• 发表时间: 2023
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Urquijo, Helena D.;Soares, Ana Goncalves R.;Fraser, Abigail;Howe, Laura;Carter, Alice
• 通讯作者: Carter, Alice

Efficacy of metformin targets on cardiometabolic health in the general population and non-diabetic individuals: a Mendelian randomization study.

• DOI: 10.1016/j.ebiom.2023.104803
• 发表时间: 2023-10
• 期刊: EBioMedicine
• 影响因子: 11.1

A lifecourse Mendelian randomization study uncovers age-dependent effects of adiposity on asthma risk.

• DOI: 10.1016/j.isci.2023.108356
• 发表时间: 2023-12-15
• 期刊: ISCIENCE
• 影响因子: 5.8
• 作者: Urquijo, Helena;Leyden, Genevieve M.;Smith, George Davey;Richardson, Tom G.
• 通讯作者: Richardson, Tom G.