Containment Level (CL) 3 laboratories and CL2/3 insectaries

遏制等级 (CL) 3 实验室和 CL2/3 昆虫房

• 批准号: MC_UU_00034/8
• 负责人: Emilie Pondeville
• 金额: $ 295.74万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00034%2F8
• 关键词: Containment; Level; CL; laboratories; CL2

The containment level (CL) 3 facilities are a suite of laboratories that allow for the study of a range of viruses that can cause serious human or animal disease. These state-of-the-art facilities provide a secure and highly regulated environment for the CVR to conduct cutting edge virology in both cell culture and animal or arthropod models. The CVR works closely with the Health & Safety Executive and other regulatory authorities to ensure the highest levels of training are given to our users and ensuring work can be carried out safely with HG3 viruses.Vector-borne diseases account for more than 17% of all infectious diseases. Using our state-of-the-art CL2 and CL3 insectaries, we study the interactions between vectors (mosquitoes and ticks) and the viruses they transmit. This will allow a better understanding of vector-borne disease emergence and spread, and ultimately lead to the development of vector control strategies to tackle these diseases. In addition, these facilities can be used to monitor and respond rapidly to new and re-emerging arboviral diseases

3级防护设施是一套实验室，可用于研究一系列可能导致严重人类或动物疾病的病毒。这些最先进的设施为CVR提供了一个安全和高度监管的环境，可以在细胞培养和动物或节肢动物模型中进行尖端病毒学研究。CVR与健康与安全执行局和其他监管机构密切合作，确保为我们的用户提供最高水平的培训，并确保可以安全地使用HG3病毒进行工作。媒介传播疾病占所有传染病的17%以上。使用我们最先进的CL2和CL3昆虫，我们研究了媒介（蚊子和蜱）与它们传播的病毒之间的相互作用。这将有助于更好地了解病媒传播疾病的出现和传播，并最终导致制定病媒控制战略，以应对这些疾病。此外，这些设施可用于监测和迅速应对新的和重新出现的虫媒病毒疾病

项目成果

The Timing and Magnitude of the Type I Interferon Response Are Correlated with Disease Tolerance in Arbovirus Infection.

• DOI: 10.1128/mbio.00101-23
• 发表时间: 2023-06-27
• 期刊: MBIO
• 影响因子: 6.4
• 作者: Hardy, Alexandra;Bakshi, Siddharth;Furnon, Wilhelm;MacLean, Oscar;Gu, Quan;Varjak, Margus;Varela, Mariana;Aziz, Muhamad Afiq;Shaw, Andrew E. E.;Pinto, Rute Maria;Ruiz, Natalia Cameron;Mullan, Catrina;Taggart, Aislynn E. E.;Filipe, Ana Da Silva;Randall, Richard E. E.;Wilson, Sam J. J.;Stewart, Meredith E. E.;Palmarini, Massimo
• 通讯作者: Palmarini, Massimo

Evaluation of an Engineered Zika Virus-Like Particle Vaccine Candidate in a Mosquito-Mouse Transmission Model.

• DOI: 10.1128/msphere.00564-22
• 发表时间: 2023-04-20
• 期刊: mSphere
• 影响因子: 4.8

Comparative analysis of pulmonary immunopathology in COVID-19 patients and experimentally SARS-CoV-2 infected hamsters

• DOI: 10.1016/j.jcpa.2023.03.029
• 发表时间: 2023-06-10
• 期刊: Journal of Comparative Pathology
• 影响因子: 0.8

Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning.

• DOI: 10.1371/journal.ppat.1011589
• 发表时间: 2023-11
• 期刊: PLoS pathogens
• 影响因子: 6.7