权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The immunopathology of multiple sclerosis

多发性硬化症的免疫病理学

基本信息

批准号：
MC_UU_00036/3
负责人：
Lars Fugger
金额：
$ 372.96万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Intramural
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=MC_UU_00036%2F3
关键词：
immunopathology multiple sclerosis

项目摘要

Multiple sclerosis (MS) is the most common neurological disease in young adults, afflicting more than 2.5 million people worldwide. However, it remains extremely difficult to diagnose in its earliest stages owing to the complex nature of initial symptoms. Furthermore, treatment options are constrained by our lack of understanding of what causes MS and the biological events that that may change in patients over time. Together, a significant delay in starting treatment and a lack of appropriate treatment options means that most patients experience cumulative and long-term disability.Accordingly, our research aims to study this complex disease by exploring the role of immune cells at different disease stages and under different conditions, as well as how they interact with cells within the brain and spinal cord. As treatments based on genetic associations are twice as likely to prove successful, data obtained from genome-wide association studies (GWAS) will form an integral part of our research platform.As part of a highly collaborative team of scientists and clinicians based at a world-leading university research hospital, we aim to dissect the underlying processes that control how the immune system behaves in patients at different stages of disease and how this affects cells within the brain and spinal cord. In combination with our genetic insights and experimental models, we aim to harness this new knowledge to discover better and safer treatment options for patients.

多发性硬化症（MS）是年轻人中最常见的神经系统疾病，全球有250多万人受到影响。然而，由于最初症状的复杂性，在其最初阶段诊断仍然非常困难。此外，由于我们对MS的病因以及患者可能随时间变化的生物学事件缺乏了解，治疗选择受到限制。在开始治疗的显著延迟和缺乏适当的治疗方案意味着大多数患者经历累积和长期的残疾。因此，我们的研究旨在通过探索免疫细胞在不同疾病阶段和不同条件下的作用，以及它们如何与大脑和脊髓内的细胞相互作用来研究这种复杂的疾病。由于基于遗传关联的治疗被证明成功的可能性是其他治疗的两倍，因此从全基因组关联研究（GWAS）获得的数据将成为我们研究平台的一个组成部分。作为世界领先的大学研究医院的科学家和临床医生高度合作团队的一员，我们的目标是剖析在疾病的不同阶段控制患者免疫系统行为的潜在过程，以及这如何影响大脑内的细胞，脊髓结合我们的遗传见解和实验模型，我们的目标是利用这些新知识为患者发现更好，更安全的治疗方案。