Harnessing antigen-specific T cell immunity in time and space

Koohy教授的研究小组深入研究了免疫系统的复杂世界，以了解它如何对抗疾病。我们专注于一种称为T细胞的免疫细胞，它在保护我们的身体方面发挥着关键作用。这些T细胞通过识别被感染细胞表面的特定分子（称为抗原）来识别有害的入侵者。尽管这一进程很重要，但许多细节仍不清楚。为了解开这些谜团，该团队使用了机器学习和单细胞创新实验等先进技术。我们的目标是创建T细胞在不同情况下用于检测抗原的分子的详细图谱。我们还在努力了解T细胞如何在感染期间或接种疫苗后对不同情况作出反应。这涉及研究T细胞表达的分子随时间和身体不同部位的变化模式。我们还在探索T细胞，它可以识别入侵者，而不需要使用通常的标记。为了破解这些谜题，我的团队将基于计算机的方法与对免疫系统如何工作的深入了解相结合。我们正在与来自世界各地的专家合作，将这些复杂的免疫防御规则拼凑在一起。最终，这项研究可能会在我们如何理解和治疗疾病方面取得突破。

The research undertaken by Prof. Koohy’s group delves into the intricate world of the immune system to understand how it fights off diseases. We focus on a type of immune cell called T cells, which play a key role in protecting our bodies. These T cells recognize harmful invaders by identifying specific molecules, known as antigens, on the surface of infected cells. Despite the importance of this process, many details remain unclear. To unravel these mysteries, the team uses advanced techniques like machine learning and innovative experiments with single cells.Our goal is to create a detailed map of the molecules that T cells use to detect antigens in different contexts. We're also working on understanding how T cells respond to different situations, during infections or following administration of vaccines. This involves studying the changing patterns of molecules expressed by T cells over time and in different parts of the body. We're also exploring T cells that can recognize invaders without using the usual markers. To crack these puzzles, my team combines computer-based methods with deep knowledge of how the immune system works. We're collaborating with experts from around the world to piece together these intricate rules of immune defence. Ultimately, this research could lead to breakthroughs in how we understand and treat diseases.