DEVELOPMENT & RELAPSE OF OPPORTUNISTIC INFECTIONS AND TUBERCULOSIS PREDICTION

发展

• 批准号: 5201107
• 负责人: Henry Masur
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201107
• 关键词: AIDS /HIV diagnosis; HIV infections; blood chemistry; cytomegalovirus; human tissue; opportunistic infections; polymerase chain reaction; prognosis; rapid diagnosis; relapse /recurrence; tuberculosis

In patients with HIV and other immunosuppressive diseases, one strategy for preventing infectious processes has been chemoprophylaxis or long term suppression. However, drug toxicity and development of pathogen resistance has made this less attractive, as has the complexity of resulting drug regimens. Another approach would be detected of signal in serum or buffy coats by PCR for pathogens such as MAX, CMV, TB, PCP, and perhaps others. PCR is being adapted for rapid screening. Initial efforts will involve CMV and MAC. Laboratory samples are being tested and quantitative standards developed. A second stage of development will involve human samples. A third stage will involve prospective monitoring of patients. This strategy is a major change from current emphasis on expensive and toxic drugs which are difficult to comply with. Proper probes, sample types, and populations need to be defined.

对于艾滋病毒和其他免疫抑制疾病的患者，一种策略