Endothelial Function in Normal Volunteers

正常志愿者的内皮功能

• 批准号: 7332175
• 负责人: Henry Masur
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7332175
• 关键词: Endothelial; Function; Normal; Volunteers

Lopinavir-ritonavir is one of the most commonly used antiretroviral therapy. It also produces lipid abnormalities. Thus, an important part of investigating factors contributing to atherosclerosis would be to determine if this drug can adversely influence endothelial cells in the absence of HIV infection or low CD4 counts. This would suggest that this drug directly or indirectly could predispose to atherosclerosis. Endothelial function is an important contributor to atherosclerosis. Invasive and non-invasive methods to evaluate endothelial cell function have been validated as predictors of coronary artery disease. These techniques have been used at NIH for clinical investigation for many years. This protocol is designed to determine whether there is a pathologic effect on endothelial function from the lopinavir-ritonavir. By measuring endothelial function in HIV non-infected subjects both before and after four weeks of therapy, we will be able to investigate whether the medications have a direct toxic effect on the endothelium. Collection of metabolic data will allow us to evaluate whether endothelial function occurs in conjunction or separate from lipoprotein and glucose metabolic changes. As ARV options increase, it may be possible to choose specific regimens that may minimize acceleration of cardiovascular risk factors associated with endothelial dysfunction, especially in patients with other cardiovascular risk factors. These findings may help elucidate the pathophysiology of premature cardiovascular disease in HIV positive patients and also plan interventions to minimize endothelial dysfunction and subsequent cardiovascular disease. The study has been completed. Surprisingly, lopinavir-ritonavir has no adverse effects on endothelial function in this study. This has important implications regarding the pathogenesis of HIV associated coronary artery disease.

洛匹那韦-利托那韦是最常用的抗逆转录病毒疗法之一。它还会导致脂质异常。因此，研究导致动脉粥样硬化的因素的一个重要部分是确定在没有HIV感染或CD4计数低的情况下，这种药物是否会对内皮细胞产生不利影响。这表明该药物可直接或间接导致动脉粥样硬化。内皮功能是动脉粥样硬化的重要因素。评估内皮细胞功能的侵入性和非侵入性方法已被证实是冠状动脉疾病的预测指标。这些技术已在美国国立卫生研究院用于临床研究多年。