DC Partnership for HIV/AIDS Progress (DC PFAP)

华盛顿特区艾滋病毒/艾滋病进展伙伴关系 (DC PFAP)

• 批准号: 9154083
• 负责人: Henry Masur
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9154083
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adherence; Affect; African American; Anti-Retroviral Agents; Area; Blood; Cardiovascular Diseases; Caring; Cities; Clinic; Collaborations; Communities; Community Healthcare; Comorbidity; Data; Databases; Development; District of Columbia; Enrollment; Epidemic; Extramural Activities; Family Practice; Funding; Genotype; Guidelines; HIV; HIV Infections; Health; Health Policy; Hepatitis B; Hepatitis C; Hepatitis C virus; Image; Infection; Intervention; Joints; Kidney Diseases; Leadership; Life; Liver diseases; Malignant Neoplasms; Medical; Mental Depression; Mental Health; Metabolic Diseases; Minority; Mission; Morbidity - disease rate; National Institute of Allergy and Infectious Disease; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; Neurocognitive; Outcome; Patients; Pharmaceutical Preparations; Population; Prevalence; Prevention; Prevention Protocols; Prevention Research; Primary Health Care; Protocols documentation; Provider; Public Health Schools; Recruitment Activity; Regimen; Research; Research Personnel; Risk Behaviors; Safety; Schedule; Science; Services; Sexually Transmitted Diseases; Site; Specialist; Testing; Therapeutic; Time; Tissues; Underinsured; Underrepresented Minority; Underserved Population; United States National Institutes of Health; Universities; Virus Diseases; Washington; Woman; Work; base; care delivery; co-infection; cognitive ability; cohort; community based treatment; expectation; follow-up; health care service organization; health data; improved; men; mortality; multidisciplinary; patient population; programs; response; therapy duration; tool; virology

During this past year DC PFAP has made substantial progress in the following areas 1. The DC Cohort database has over 8000 patients enrolled. The program is enrolling at all sites. Data analysts are looking at merged data. This database is providing unique, real time granularity for the city HIV population. The data is meshed with the DC Department of Health data base to enhance its utility for analyzing the city epidemic. 2. The prevention protocols have exceeded expectations in terms of enrolling African American men and women in studies to assess their risk behavior. Based on superior enrollment and retention of subjects, the DC investigators have been invited to participate In PREP studies have been completed with DC sites being among the leaders in enrollment and retention in follow up. 3. The HPTN test and treat protocol is actively enrolling at DC sites. 4. The HCV program has active interventional studies: including SYNERGY and CONQUER. The ERADICATE and SPARE studies were recently completed. This year we began the ACSEND protocol, enrolling 600 patients from the DC clinics evaluating the efficacy, implementation, safety, and long-term outcomes of community based treatment of hepatitis C genotype 1 monoinfection and HIV-coinfection utilizing ledipasvir/sofosbuvir (LDC/SOF) as per treatment guidelines. All studies performed are investigator initiated studies which recruit almost exclusively among the citys underserved populations. Studies completed in the past three years have included unique studies of various combination regimens in HIV infected and uninfected patients. The program has focused on science based studies looking at mechanisms of action and correlates of response in tissue and in blood. The program has also focused on approaches that can shorten the duration of therapy, and which can utilize non specialists for delivery of care. 5. The mental health program has launched studies at Family Medicine investigating optimal ways to assess depression in minority communities. This assessment tool will be useful for determining what interventions are useful to improve adherence with HIV and HCV therapeutics. 6. Neurocognitive Studies. A multidisciplinary group including investigators from NINDS, NIMH, NIAID and CC are developing strategies to form a cohort of patients with a range of cognitive abilities who can be followed and intensively studied prospectively. These studies use NIH intramural imaging facilities and NINDS flow and virology facilities to characterize this patient population much more intensively than extramural studies are currently doing. This project is fulfilling all of its missions ahead of schedule. The program is working effectively with the DC Center for AIDS Research and with community and academic partners to build a strong AIDS research network in DC.

在过去的一年里，DC PFAP在以下领域取得了重大进展 1. DC队列数据库入组了8000多名患者。 该计划正在所有研究中心注册。 数据分析师正在研究合并数据。该数据库为城市艾滋病毒感染者提供独特的、真实的时间粒度。 这些数据与DC卫生部数据库相结合，以提高其分析城市流行病的实用性。 2. 预防方案在招募非裔美国人男性和女性参与研究以评估其风险行为方面超出了预期。 基于受试者的上级入组和保留，DC研究者已被邀请参与PREP研究，DC研究中心在入组和保留随访方面处于领先地位。 3. HPTN测试和治疗方案正在DC研究中心积极招募。 4. HCV项目有积极的干预性研究：包括SYNERGY和CONQUER。 最近完成了ERADICATE和SPARE研究。今年，我们开始了ACSEND方案，从DC诊所招募了600名患者，评估根据治疗指南使用ledipasvir/sofosbuvir（LDC/SOF）治疗丙型肝炎基因型1单一感染和HIV合并感染的社区治疗的疗效，实施，安全性和长期结果。 所有进行的研究都是由调查人员发起的研究，几乎只在城市服务不足的人群中招募。在过去三年中完成的研究包括在艾滋病毒感染和未感染患者中进行的各种联合治疗方案的独特研究。该计划的重点是基于科学的研究，研究组织和血液中的作用机制和反应相关性。 该方案还侧重于可以缩短治疗时间的方法，并可以利用非专家提供护理。 5. 心理健康计划已经在家庭医学中开展了研究，调查评估少数民族社区抑郁症的最佳方法。该评估工具将有助于确定哪些干预措施有助于改善HIV和HCV治疗的依从性。 6. 神经认知研究。一个多学科小组，包括来自NINDS，NIMH，NIAID和CC的研究人员正在制定策略，以形成一个具有一系列认知能力的患者队列，这些患者可以进行前瞻性随访和深入研究。这些研究使用NIH内部成像设施和NINDS流动和病毒学设施来表征这一患者人群，比目前正在进行的外部研究更加深入。 该项目正在提前完成其所有任务。该计划正在与DC艾滋病研究中心以及社区和学术合作伙伴有效合作，以在DC建立一个强大的艾滋病研究网络。