Endothelial Dysfunction as a Risk Factor in HIV

内皮功能障碍是艾滋病毒的危险因素

• 批准号: 7215788
• 负责人: Henry Masur
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7215788
• 关键词: AIDS therapy; HIV infections; antiAIDS agent; antihypercholesterolemic agent; atherosclerosis; biomarker; blood circulation; blood flow measurement; clinical research; disease /disorder onset; disease /disorder proneness /risk; drug adverse effect; human subject; hyperlipidemia; medical complication; patient oriented research

Premature atherosclerosis is an emerging problem for patients with HIV infection who are treated with antiretroviral drugs. It is not clear whether these complications are related to HIV, the drugs, or the dyslipidemias that the drugs produce. A study has been developed to look at flow mediated dilation in patients with HIV treated with antiretroviral drugs. This technique is a surrogate for coronary artery disease that is well established, and is an assessment of endothelial function. The prevastatin arm of the study has been fully accrued. The data have been analyzed to assess the effect of drug on endothelial function. It is not clear from this study that prevastatin alters forearm blood flow. A manuscript is in review.

过早的动脉粥样硬化是一个新出现的问题，艾滋病毒感染的患者谁是抗逆转录病毒药物治疗。目前尚不清楚这些并发症是否与艾滋病毒、药物或药物产生的血脂异常有关。已经开展了一项研究，以观察接受抗逆转录病毒药物治疗的HIV患者的血流介导的扩张。该技术是一种公认的冠状动脉疾病的替代方法，是一种内皮功能的评估方法。 本研究的普伐他汀组已完全累积。分析数据以评估药物对内皮功能的影响。这项研究尚不清楚普伐他汀是否会改变前臂血流。一份手稿正在审阅中.