Endothelial Dysfunction as a Risk Factor in HIV
Endothelial Dysfunction as a Risk Factor in HIV
批准号:
7215788
负责人:
Henry Masur
金额:
$0.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
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中文摘要
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英文摘要
Premature atherosclerosis is an emerging problem for patients with HIV infection who are treated with antiretroviral drugs. It is not clear whether these complications are related to HIV, the drugs, or the dyslipidemias that the drugs produce. A study has been developed to look at flow mediated dilation in patients with HIV treated with antiretroviral drugs. This technique is a surrogate for coronary artery disease that is well established, and is an assessment of endothelial function.
The prevastatin arm of the study has been fully accrued. The data have been analyzed to assess the effect of drug on endothelial function. It is not clear from this study that prevastatin alters forearm blood flow. A manuscript is in review.
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