Magnetic Resonance Imagery Study Of Avascular Necrosis O

股骨头坏死的磁共振成像研究

• 批准号: 6993907
• 负责人: Henry Masur
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6993907
• 关键词: HIV infections; bioimaging /biomedical imaging; bone imaging /visualization /scanning; bone necrosis; clinical research; diagnosis design /evaluation; disease /disorder etiology; disease /disorder proneness /risk; functional ability; hip; human subject; longitudinal human study; magnetic resonance imaging; medical complication; pain

In 2002 we reported the occurence of avascular necrosis of bone (usually the hip) in 15 asymptomatic patients with HIV disease. We are currently assessing the natural history of avascular necrosis in the asymptomatic additional ten patients with symptomatic disease. The occurence of pain and functional disability is being assessed. The development of AVN at other sites is also being evaluated by yearly MRIs. The study will elucidate natural history and risk factors for this unexpected complication of treated HIV disease. This follow-up continues. A formal evaluation will be performed after 3-5 years of follow-up in order to determine natural history of this disorders.

在2002年，我们报道了15例无症状的HIV感染患者发生骨（通常是髋关节）缺血性坏死。我们目前正在评估另外10例无症状性有症状性疾病患者的缺血性坏死自然史。正在评估疼痛和功能障碍的发生情况。其他部位的AVN的发展也正在通过每年的MRI进行评估。这项研究将阐明这种治疗艾滋病毒疾病的意外并发症的自然史和风险因素。这一后续行动仍在继续。将在3-5年随访后进行正式评估，以确定这种疾病的自然史。