Temporally patterned closed-loop stimulation for therapy of brain disorders

用于治疗脑部疾病的时间模式闭环刺激

• 批准号: MC_UU_12024/1
• 负责人: Peter Brown
• 金额: $ 389.64万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_12024%2F1
• 关键词: Temporally; patterned; closed; loop; stimulation

In Parkinson’s disease and tremor, the electrical activity in several different parts of the brain becomes abnormally rhythmic. This increase in rhythmic activity stops the brain controlling movement in a normal way. These diseases can be treated by placing electrodes in the parts of the brain that are abnormally rhythmic and applying continuous electrical pulses. This treatment increases the amount of normal movement, but it can also cause side effects by disrupting the brains healthy activity. Our aim is to improve such brain pacemaker treatments.We will record the rhythmic brain activity and use its features to decide when and how to stimulate in a way that will further increase normal movements and decrease side effects. Firstly, we will use the strength of rhythmic activity to decide when to turn the stimulation on and off. Secondly, we can time a pulse of electricity on a specific part of the rhythm to improve movements as efficiently as possible. This is similar to pushing someone on a swing; pushing them at one point will make them go faster, but at another will make them slow down. We will use experiments in animal models to find the most effective and safest techniques and then test these in patients.

在帕金森病和震颤中，大脑几个不同部位的电活动变得异常有节奏。这种节奏活动的增加会阻止大脑以正常的方式控制运动。这些疾病可以通过将电极放置在大脑节奏异常的部分并施加连续的电脉冲来治疗。这种治疗增加了正常运动的量，但它也可能通过破坏大脑健康活动而引起副作用。我们的目标是改善这种大脑起搏器治疗。我们将记录有节奏的大脑活动，并利用其特征来决定何时以及如何刺激，以进一步增加正常运动并减少副作用。首先，我们将使用节律活动的强度来决定何时打开和关闭刺激。其次，我们可以在节奏的特定部分定时脉冲，以尽可能有效地改善运动。这就像推人荡秋千一样，在一个点推他们会让他们走得更快，但在另一个点推他们会让他们慢下来。我们将在动物模型中进行实验，以找到最有效和最安全的技术，然后在患者身上进行测试。

项目成果

Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input

帕金森病揭示了丘脑底核神经元对 β 频率皮质输入的潜在敏感性

• DOI: 10.1101/513234
• 发表时间: 2019
• 作者: Baaske M

Additional file 1 of Identifying and modulating distinct tremor states through peripheral nerve stimulation in Parkinsonian rest tremor

附加文件 1 通过周围神经刺激识别和调节帕金森静止性震颤的不同震颤状态

• DOI: 10.6084/m9.figshare.17693378
• 发表时间: 2021
• 作者: Arruda B

Excessive neural synchrony in Machado-Joseph disease responsive to subthalamic nucleus stimulation.

马查多-约瑟夫病中的过度神经同步对丘脑底核刺激有反应。

• DOI: 10.1002/mds.26173
• 发表时间: 2015
• 期刊: official journal of the Movement Disorder Society
• 作者: Anzak A

Subcortical evoked activity and motor enhancement in Parkinson's disease.

• DOI: 10.1016/j.expneurol.2015.12.004
• 发表时间: 2016-03
• 期刊: Experimental neurology
• 影响因子: 5.3
• 作者: Anzak A;Tan H;Pogosyan A;Khan S;Javed S;Gill SS;Ashkan K;Akram H;Foltynie T;Limousin P;Zrinzo L;Green AL;Aziz T;Brown P
• 通讯作者: Brown P

Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo.

帕金森氏病揭示了丘脑核神经元对体内β-频率皮质输入的潜在灵敏度。

• DOI: 10.1016/j.nbd.2020.105119
• 发表时间: 2020-12
• 期刊: Neurobiology of disease
• 影响因子: 6.1
• 作者: Baaske MK;Kormann E;Holt AB;Gulberti A;McNamara CG;Pötter-Nerger M;Westphal M;Engel AK;Hamel W;Brown P;Moll CKE;Sharott A
• 通讯作者: Sharott A