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ULTRAVIOLET RADIATION INDUCED SKIN CANCER

ULTRAVIOLET RADIATION INDUCED SKIN CANCER
紫外线辐射诱发的皮肤癌
批准号：
5202137
负责人：
J E FRENCH
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5202137
关键词：
DNA damage DNA repair biomarker cancer risk delayed hypersensitivity genetic polymorphism genetic strain host neoplasm interaction human genetic material tag laboratory mouse neoplasm /cancer genetics phenotype radiation carcinogenesis radiation genetics radiation immunosuppression radiation resistance radiation sensitivity restriction fragment length polymorphism skin neoplasms tumor necrosis factor alpha ultraviolet radiation

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中文摘要
翻译
已知紫外线照射引起的免疫抑制和遗传损伤
英文摘要
Both UVR induced immunosuppression and genetic damage are known to contribute to skin cancer in humans and experimental animals. Failure of the skin immune system to respond after UVR exposure to preneoplastic cells bearing neoantigens may contribute significantly to the development of skin cancer. UVR induced suppression of delayed-type hypersensitivity (DTH) is functionally similar and may be used as a marker to determine individual susceptibility to UV-induced immunosuppression as a risk factor for the induction of skin cancer in humans and selected mouse strains. In addition, UVR induced DNA damage and individual DNA repair efficiencies may also contribute to host susceptibility for skin cancer. Recent evidence indicates that tumor necrosis factor alpha (TNFalpha) may mediate UVR induced immune suppression of DTH in humans and in selected strains of mice. Genetic polymorphisms at the TNFalpha locus (intron 1 BamHI RFLP and a 5
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