SEARCH FOR DNA MARKERS LINKED TO MANIC DEPRESSIVE ILLNESS IN THE OLD ORDER AMISH

在旧秩序阿米什人中寻找与躁狂抑郁症相关的 DNA 标记

基本信息

  • 批准号:
    5203782
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
  • 资助国家:
    美国
  • 起止时间:
  • 项目状态:
    未结题

项目摘要

We are performing a systematic screening of the human genome in order to identify genes responsible for manic depressive disorder in the Old Order Amish. We are utilizing a large, multigenerational Old Order Amish pedigree with many affected individuals. By using this multigenerational pedigree with a high incidence of a disease manifested by a relatively consistent and definable phenotype, we reduce uncertainties in analysis that could otherwise be introduced as a consequence of genetic heterogeneity, variable mode of inheritance, phenocopies, and/or penetrance. Candidate genes have been studied. Highly informative markers particularly microsatellites scattered across the genome are used to obtain genotypings. DNA of affected individuals is also analyzed to ascertain whether trinucleotide expansions play a role in the pathogenesis of manic-depressive illness. Due to the lack of any definitive biological marker for bipolar illness (manic-depressive disorder), the linkage analyses are performed using several clinical hierarchies. Parametric (LOD scored, maximum likelihood) and nonparametric (affected sib pair, affected pedigree member, etc.) analyses are carried out. Computer simulations using specific models are used to demonstrate the power of analyses. Simulation and data analysis includes several models of inheritance and diagnostic hierarchies, as well as polygenic etiologies. As marker genotypings are accumulated, the diagnostic data is updated, and our collection of cell lines from both normal and affected family member is being expan ded. The availability of longitudinal follow-up evaluation for family members and the high frequency of manic depressive illness in the pedigree make the Old Order Amish pedigree a valuable resource in the search for the genetic loci involved in bipolar affective disorder.
我们正在对人类基因组进行系统筛选,以便

项目成果

期刊论文数量(0)
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E I GINNS其他文献

E I GINNS的其他文献

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{{ truncateString('E I GINNS', 18)}}的其他基金

MOLECULAR GENETICS OF LYSOSOMAL DISORDERS
溶酶体疾病的分子遗传学
  • 批准号:
    3969060
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MOLECULAR GENETIC STUDIES OF THE MUCOPOLYSACCHARIDOSES
粘多糖的分子遗传学研究
  • 批准号:
    3969059
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
TRANSGENIC ANIMAL MODELS OF HUMAN INHERITED DISORDERS
人类遗传性疾病的转基因动物模型
  • 批准号:
    6162911
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
STUDIES OF GAUCHER DISEASE AND OTHER NEUROGENETIC DISORDERS TOWARD GENE THERAPY
戈谢病和其他神经遗传疾病的基因治疗研究
  • 批准号:
    3845237
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
SEARCH FOR DNA MARKERS LINKED TO MANIC DEPRESSIVE ILLNESS IN THE OLD ORDER AMISH
在旧秩序阿米什人中寻找与躁狂抑郁症相关的 DNA 标记
  • 批准号:
    3845403
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
GENE REGULATION WITHIN THE NERVOUS SYSTEM
神经系统内的基因调控
  • 批准号:
    3921991
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
CORRECTION OF INHERITED PROTEIN DEFICIENCEIS BY GENE THERAPY
通过基因疗法纠正遗传性蛋白质缺陷
  • 批准号:
    2578718
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MOLECULAR GENETICS OF INHERITED NEUROLOGIC AND PSYCHIATRIC DISORDERS
遗传性神经和精神疾病的分子遗传学
  • 批准号:
    2578719
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MOLECULAR GENETICS OF INHERITED NEUROLOGIC AND PSYCHIATRIC DISORDERS
遗传性神经和精神疾病的分子遗传学
  • 批准号:
    3880914
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
APPLICATION OF GENE TRANSFER TO CORRECT INHERITED ENZYME DEFICIENCIES
应用基因转移纠正遗传性酶缺陷
  • 批准号:
    4696966
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

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裸盖菇素辅助双相抑郁心理治疗:功能磁共振成像情绪处理试点研究
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