Smartphone-based mindfulness intervention for reducing stressrelated CVD risk

基于智能手机的正念干预可降低压力相关的心血管疾病风险

• 批准号: 10593307
• 负责人: THOMAS WILSON KAMARCK
• 金额: $ 27.83万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-16 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593307
• 关键词: Acceleration; Acute; Address; Aftercare; Age; Age Factors; Ambulatory Monitoring; Atherosclerosis; Behavioral; Benchmarking; Biological Markers; Blood Pressure; Cardiac; Cardiovascular Diseases; Cardiovascular system; Cellular Phone; Chronic; Clinical; Clinical Trials; Computer Models; Conflict (Psychology); Data; Data Correlations; Detection; Development; Effectiveness; Elderly; Enrollment; Environment; Event; Exhibits; Experimental Designs; Exposure to; Goals; Health; Hypertension; Intervention; Laboratories; Life; Life Stress; Link; Literature; Measures; Mindfulness Training; Modeling; Outcome; Participant; Phase II Clinical Trials; Physiological; Population; Psyche structure; Psychosocial Stress; Public Health; Randomized; Randomized, Controlled Trials; Recording of previous events; Recurrence; Reporting; Research; Risk; Risk Factors; Sampling; Source; Standardization; Stress; Testing; Time; Training; Training Programs; Treatment/Psychosocial Effects; Work; acute stress; adaptive intervention; cardiovascular disorder risk; cohort; design; disorder risk; mHealth; middle age; mindfulness; mindfulness intervention; mortality; occupational stress; perceived stress; portability; pre-clinical; programs; recruit; response; satisfaction; side effect; social; stress reactivity; stress reduction; stressor; tool; treatment as usual; treatment duration; treatment effect; usual care arm

SUMMARY: Smartphone-based mindfulness intervention for reducing stress-related CVD risk Chronic psychosocial stress has been shown to be associated with increased risk for cardiovascular disease (CVD), and exaggerated stress-related cardiovascular reactivity (CVR) has also been linked with elevated CVD risk. Most of the evidence in these literatures is based upon correlational data to date. Progress in characterizing and ameliorating these effects requires the development of standardized intervention tools designed to alter stress exposure and reactivity. Mobile health interventions may provide a useful approach to this problem. We have identified two specific daily life measures of psychosocial stress and stress reactivity, measured by ambulatory monitoring, that are associated with markers of subclinical atherosclerosis. We have also developed a smartphone-based mindfulness training program that appears to produce significant reductions in related measures of daily life stress and acute stress-related physiological responding. The current study is designed to examine whether this mobile health intervention is feasible and effective in addressing the stress-related targets we have identified, in a population selected for vulnerability to stress and to CVD. We will examine whether additional practice prompts that are presented during daily life (in the spirit of “Just-in-Time Adaptive Interventions” or JITAIs) increase the magnitude or duration of treatment effects, and we will also explore whether we can develop a model to assist us in identifying the circumstances in which automated prompting may be fruitfully employed as part of this treatment. The goal is to produce a scalable mobile health intervention that can be shown to reduce progression of preclinical CVD as part of a subsequent Phase 2 clinical trial. RELEVANCE: Developing interventions for reducing the effects of psychosocial stress on cardiovascular disease is of critical importance for public health.

总结： 基于智能手机的正念干预可降低压力相关的心血管疾病风险 慢性心理社会压力已被证明与心血管疾病风险增加有关 (CVD)过度的压力相关心血管反应性（CVR）也与心血管疾病的升高有关 风险这些文献中的大多数证据都是基于迄今为止的相关数据。表征进展 改善这些影响需要开发标准化的干预工具， 应力暴露和反应性。移动的卫生干预措施可能为解决这一问题提供一个有用的方法。我们 已经确定了心理社会压力和压力反应性的两个具体日常生活指标，通过以下方式测量 与亚临床动脉粥样硬化标志物相关的动态监测。我们还开发了 一个基于智能手机的正念训练计划，似乎产生显着减少相关的 日常生活应激和急性应激相关生理反应的测量。本研究旨在 检查这种移动的健康干预措施在解决与压力相关的目标方面是否可行和有效 我们已经确定，在一个人口选定的脆弱性，以压力和心血管疾病。我们将研究是否 在日常生活中呈现的附加练习提示（本着“即时自适应”的精神 干预”或JITAIs）增加治疗效果的幅度或持续时间，我们还将探讨是否 我们可以开发一个模型来帮助我们识别自动提示可能被 作为这种治疗的一部分而卓有成效地使用。我们的目标是产生一个可扩展的移动的健康干预， 作为后续2期临床试验的一部分，可以显示出减少临床前CVD的进展。 相关性： 开发干预措施以减少心理社会压力对心血管疾病的影响至关重要 对公共卫生的重要性。