PERITONEAL DIALYSIS ADEQUACY IN CHILDREN

儿童腹膜透析的充分性

• 批准号: 5218054
• 负责人: SUSAN MENDLEY
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5218054
• 关键词: body composition; child (0-11); child psychology; clinical research; continuous ambulatory peritoneal dialysis; dietary proteins; growth /development; human subject; longitudinal human study; malnutrition; nutrition related tag; patient care management

Pediatric peritoneal dialysis patients may suffer from growth retardation, malnutrition and impaired neurocognitive development. Attempts to address these individual problems have been limited by inconsistent dialysis delivery and the lack of an age-appropriate definition of dialysis adequacy. Proposed is a randomized, prospective, cross-over comparison of usual and intensive peritoneal dialysis, assessing the effect of enhanced small molecule clearance on neuro- cognitive function, growth of lean body mass and dietary protein intake.

小儿腹膜透析患者可能患上生长 发育迟缓、营养不良和神经认知发育受损。 解决这些个别问题的努力受到了限制， 不一致的透析输送和缺乏适合年龄的 透析充分性的定义。 提出了一个随机的，前瞻性的， 常规和强化腹膜透析的交叉比较， 评估增强的小分子清除对神经- 认知功能、瘦体重增长和膳食蛋白质摄入。