IMPACT OF WT REDUCTION INTERVENTION ON BP & CV RISK FACTORS IN OBESE CHILDREN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 美国儿童肥胖症的增加预示着高血压和心脏病的增加，这可能会使过去几十年取得的成就化为乌有。心脏病可能不再是老年人的疾病。为了满足日益增长的需求，Mt。位于巴尔的摩的华盛顿儿科医院针对超重和肥胖的儿童和青少年提供了一个多学科的干预计划，称之为“聪明体重”，其中包括家庭营养教育、儿童及其家人的心理咨询和现场锻炼。由于参加了体重智能计划，一些孩子会减轻体重，但所有人都会增加他们的活动水平，并在一定程度上改变他们的饮食模式。这些策略可能对抵消肥胖的影响很重要，并可能改善心血管疾病的早期症状。我们计划在孩子们参加Weigh Smart计划之前和之后进行研究。我们将使用可穿戴血压设备评估他们的血压。早期心血管疾病的血液和尿液测试将在项目前后进行评估，以更好地了解肥胖导致心脏病的最早机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The increase in obesity among U.S. children portends a rise in high blood pressure and heart disease, which threaten to wipe out gains made in the last decades. Heart disease may no longer be a disease of older adults. To address this growing need, Mt. Washington Pediatric Hospital in Baltimore offers a multi-disciplinary intervention program, Weigh Smart, targeting children and adolescents who are overweight and obese which includes family nutrition education, psychological counseling for children and their families and on-site exercise sessions. As a result of participation in the Weigh Smart program, some children will lose weight, but all will increase their activity level and change their eating pattern to some degree. These strategies may be important to counteract the effects of obesity and may ameliorate early signs of cardiovascular disease. We plan to study children before and after they participate in the Weigh Smart program. We will evaluate their blood pressure using a wearable blood pressure device. Blood and urine tests of early cardiovascular disease will be evaluated before and after the program to better understand the earliest mechanisms of heart disease from obesity.