MATHEMATICAL MODELING OF HEMODIALYSIS AND MEASUREMENT OF BODY WATER

血液透析和体内水分测量的数学模型

• 批准号: 6245185
• 负责人: SUSAN MENDLEY
• 金额: $ 1.2万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-15 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245185
• 关键词: body water; cell water; child (0-11); chronic renal failure; clinical research; hemodialysis; human data; human subject; mathematical model; model design /development

Excess morbidity and mortality in the US ESRD population compared to other industrialized nations in Europe and Asia is a subject of regulatory concern and active ongoing investigation. There is evidence that a large proportion, perhaps the majority, of American hemodialysis patients receive inadequate therapy and that this may be the cause of high mortality. Children on hemodialysis suffer many of the same problems of adult patients and yet few investigations have targeted pediatric dialysis patients. Several mathematical models have been developed to describe the events that occur during and after hemodialysis treatments and to measure accurately the effective clearance of treatments. Available data suggest that models may be especially useful in measuring dialysis delivery at extremes of body size, and thus would be particularly important in small children. However, these models have been validated only in adult hemodialysis patients and have not been adequately studied in children. In this protocol, mathematical modeling of hemodialysis will be performed in children during routine dialysis sessions. In addition, this study will obtain normative data on body water spaces (total body water, intracellular water, and extracellular water) in children with chronic kidney failure to allow accurate modeling of clearances during dialysis. Data on body water spaces in children with renal failure will also be important for pharmacokinetic applications to allow predictions of drug distribution and clearances.

与美国ESRD人群相比，美国ESRD人群的发病率和死亡率过高 欧洲和亚洲的其他工业化国家是 监管机构的关注和积极的正在进行的调查。有证据表明 很大一部分，也许是大多数美国人的血液透析 患者接受的治疗不充分，这可能是导致 高死亡率。接受血液透析的儿童也会遭受同样的痛苦。 成人患者的问题，但很少有有针对性的研究 儿童透析患者。 已经开发了几个数学模型来描述这些事件 在血液透析治疗期间和之后发生的情况，并测量 准确有效地清除治疗。现有数据表明 这些模型在测量透析量时可能特别有用 体型的极端大小，因此在体型较小的 孩子们。然而，这些模型仅在成人中得到验证。 对血液透析患者和儿童的研究还不够充分。 在该方案中，将对血液透析进行数学建模 在常规透析过程中对儿童的影响。 此外，这项研究还将获得有关人体水空间的规范数据 (体内总水、细胞内水和细胞外水) 慢性肾功能衰竭儿童可以进行准确的建模 透析过程中的清除。慢性阻塞性肺疾病儿童的体水空间数据 肾功能衰竭对药物动力学的应用也很重要。 允许预测药物分布和清除。