PERITONEAL DIALYSIS ADEQUACY IN CHILDREN

儿童腹膜透析的充分性

• 批准号: 6114043
• 负责人: SUSAN MENDLEY
• 金额: $ 2.37万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6114043
• 关键词: body composition; child (0-11); child physical development; child psychology; clinical research; cognition; continuous ambulatory peritoneal dialysis; dietary proteins; human subject; human therapy evaluation; longitudinal human study; malnutrition; nutrient intake activity; nutrition related tag; patient care management

Pediatric peritoneal dialysis patients may suffer from growth retardation, malnutrition and impared neruocognitive development. Attempts to address these individual problems have been limited by inconsistent dialysis delivery and the lack of an age-appropriate definition of dialysis adequacy. Proposed is a randomized, prospective, cross-over comparison of usual and intensive peritoneal dialysis, assessing the effect of enhanced small molecule clearance on neuro-cognitive function, growth of lean body mass and dietary protein intake.

小儿腹膜透析患者可能会出现生长迟缓， 营养不良和神经认知发育受损。尝试解决 这些个别问题受到透析不一致的限制 分娩和缺乏适合年龄的透析定义 充分性。提出了一项随机、前瞻性、交叉比较 常规腹膜透析和强化腹膜透析，评估增强腹膜透析的效果 小分子清除对神经认知功能、瘦身生长的影响 质量和膳食蛋白质摄入量。