PERITONEAL DIALYSIS ADEQUACY IN CHILDREN

儿童腹膜透析的充分性

• 批准号: 3740047
• 负责人: SUSAN MENDLEY
• 金额: --
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3740047
• 关键词: child (0-11); cognition; continuous ambulatory peritoneal dialysis; dietary proteins; growth /development; human subject; malnutrition; patient care management

Pediatric peritoneal dialysis patients may suffer from growth retardation, malnutrition and impaired neurocognitive development. Attempts to address these individual problems have been limited by inconsistent dialysis delivery and the lack of an age-appropriate definition of dialysis adequacy. Proposed, is a randomized, prospective, cross-over comparison of usual and intensive peritoneal dialysis, assessing the effect of enhanced small molecule clearance on neuro cognitive function, growth of lean body mass and dietary protein intake.

儿童腹膜透析患者可能患有生长发育障碍 发育迟缓、营养不良和神经认知发育受损。 解决这些个别问题的努力受到以下限制 透析提供不一致和缺乏适合年龄的 透析充分性的定义。提出，是一种随机的，前瞻性的， 常规腹膜透析与强化腹膜透析的交叉比较， 增强的小分子清除剂对神经细胞的影响 认知功能、瘦体重增长和膳食蛋白质摄入量。