State of the Art Biomaterials Development and Characterization of the Cell-Biomaterial Interface

我们的要求符合英国再生医学平台中心“治疗递送的非细胞方法”的需求。这些仪器将支持中心内概述的项目，在再生医学治疗中进行的生物材料研究将在中心和英国受益，可能导致可翻译的原型。伦敦帝国理工学院和诺丁汉大学之间的合作记录是一流的，我们的目标是通过提交高端设备的合作投标来延续这一记录，以供我们的中心使用。这里提出的设备将从帝国理工学院和诺丁汉大学的角度研究项目中受益，因为我们的设备和仪器多年来一直提供。制造3D生物材料所需的设备包括3D打印机、静电纺丝装置、等离子体处理系统、LCMS、SEC、ElectroForce系统，以及用于细胞-材料界面表征的设备包括共聚焦拉曼系统、XPS BioCell、FTIR、Observer显微镜系统、microCT和Plunge冷冻室，以生成许多可用于翻译评估的高潜力原型。如果没有使用最高端的设备进行全面的合成优化和材料或生物表征，就无法达到这一商业评估步骤。除了直接受益于英国RMP中心的所有现有和未来成员外，我们还将提供一些设备作为国家设施，并由联合国资助核心支持。

Our request is in line with the needs of the UK Regenerative Medicine Platform Hub "Acellular Approaches for Therapeutic Delivery". These instruments will support the projects outlined within the Hub and research carried out on biomaterials for treatments in Regenerative Medicine will profit within the Hub and the UK, likely leading to translatable prototypes. The collaborative track record between Imperial College London and the University of Nottingham is stellar, and we aim to continue this record by submitting a collaborative bid for high-end equipment to be used within our Hub. The equipment proposed here will benefit the specific projects from perspective research programmes within Imperial College and the University of Nottingham, as provided by our facilities and instrumentation for many years. Equipment needs for the fabrication of 3D biomaterials include 3D printer, electrospinning rig, plasma treatment system, LCMS, SEC, ElectroForce system and for the characterisation of the cell-material interface include Confocal Raman system, XPS BioCell, FTIR, Observer microscope system, microCT and Plunge freezer to generate a number of high potential prototypes that can be assessed for translation. This step of commercial assessment cannot be reached without having performed a full round of synthetic optimisation and material or biological characterisation using the most high-end equipment available. As well as directly benefiting all current and future members of the UK RMP Hub, we will also provide some of the equipment as a National facility with core support funded from UoN.