A National Centre for Translational Hyperpolarised Magnetic Resonance

国家转化超极化磁共振中心

• 批准号: MR/M008991/1
• 负责人: Sven Plein
• 金额: $ 117.41万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM008991%2F1
• 关键词: National; Centre; Translational; Hyperpolarised; Magnetic

We have developed a new imaging method that has the potential to increase the signal in a magnetic resonance (MR) image by up to 100,000 fold. This method can potentially be used on any hospital MR scanner. Our method works by magnetically labelling substances we seek to probe without affecting their molecular structure and is therefore non-toxic. With this method it is possible to label both drugs and substances that occur naturally in the body, making the method widely applicable. In previously and currently funded work, we are developing the technical aspects of this method and seek to test it in healthy subjects. As part of the current grant application, we will create the infrastructure needed to apply this method in patients within 5 years, focussing on patients with heart disease, cancer and joint disease. Our new method has the potential to speed up and improve MR imaging in a very wide range of diseases and help in the development of new drugs.

我们已经开发出一种新的成像方法，有可能将磁共振（MR）图像中的信号提高10万倍。该方法可以潜在地用于任何医院MR扫描仪。我们的方法通过磁性标记我们试图探测的物质而不影响它们的分子结构，因此是无毒的。通过这种方法，可以标记药物和体内天然存在的物质，使该方法具有广泛的适用性。在以前和目前资助的工作中，我们正在开发这种方法的技术方面，并寻求在健康受试者中进行测试。作为当前拨款申请的一部分，我们将在5年内创建将这种方法应用于患者所需的基础设施，重点关注心脏病，癌症和关节疾病患者。我们的新方法有可能加速和改善广泛疾病的MR成像，并有助于新药的开发。

项目成果

Direct and indirect hyperpolarisation of amines using parahydrogen.

• DOI: 10.1039/c8sc00526e
• 发表时间: 2018-04-21
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Iali W;Rayner PJ;Alshehri A;Holmes AJ;Ruddlesden AJ;Duckett SB
• 通讯作者: Duckett SB

Diffusion tensor imaging in cubital tunnel syndrome.

• DOI: 10.1038/s41598-021-94211-7
• 发表时间: 2021-07-22
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Griffiths TT;Flather R;Teh I;Haroon HA;Shelley D;Plein S;Bourke G;Wade RG
• 通讯作者: Wade RG

Hyperpolarising Pyruvate through Signal Amplification by Reversible Exchange (SABRE)

通过可逆交换信号放大 (SABRE) 使丙酮酸超极化

• DOI: 10.1002/ange.201905483
• 发表时间: 2019
• 期刊: Angewandte Chemie
• 作者: Iali W

In Situ SABRE Hyperpolarization with Earth's Field NMR Detection.

现场 SABRE 超极化与地球场核磁共振检测。

• DOI: 10.3390/molecules24224126
• 发表时间: 2019
• 期刊: Molecules (Basel, Switzerland)
• 作者: Hill-Casey F

Parawasserstoff-induzierte Hyperpolarisation von Gasen

加森超极化

• DOI: 10.1002/ange.201915306
• 发表时间: 2020
• 期刊: Angewandte Chemie
• 作者: Kovtunov K