Understanding gender differences in cardiometabolic risk across the life course
了解整个生命过程中心脏代谢风险的性别差异
基本信息
- 批准号:MR/M014509/1
- 负责人:
- 金额:$ 44.25万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Fellowship
- 财政年份:2015
- 资助国家:英国
- 起止时间:2015 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Heart disease and diabetes are leading causes of death in men and women globally and in the UK. Gender differences in diabetes exist in adults. For example, diabetes is more common in men than in women. On average, overweight or obese men also develop diabetes at a lower level of fatness than overweight or obese women. However, once a woman becomes diabetic she is much more likely to develop heart disease than a diabetic man. We know that a person's risk of diabetes and heart disease begins to take shape in childhood. Even in young children the level of sugar and other substances in the blood can tell us about the risk of them developing diabetes as adults. The aim of this project is to find out if differences between men and women in terms of their diabetes and heart disease risk later in life are already evident in young boys and girls from birth all the way through childhood and into early adulthood. I will do this by comparing the amount of sugar and other substances in the blood of boys and girls from when they are born to when they are young adults. I will investigate if young boys who are overweight or obese have the same levels of sugar in their blood as young girls who are overweight or obese. This will tell us if overweight or obese boys already show a higher chance of getting diabetes compared to overweight or obese girls. I will also investigate if girls with high levels of sugar and other substances in their blood have problems with their hearts compared to boys with high level of sugars and other substances in their blood. This will tell us if the higher level of heart disease in diabetic women later in life is already detectable in the hearts of young girls with high levels of sugar and other substances in their blood, that are linked to diabetes. I will then investigate the reasons behind any differences; whether different behaviour patterns such as smoking or physical activity, biological factors such as hormones or differences in body shape which reflect different patterns of fat storage explain the differences. I will use data from two different studies that followed participants from birth across childhood into adulthood. The Avon Longitudinal Study of Parents and Children started with over 14,000 pregnant women in Bristol in 1991/1992 and their children have been followed ever since, now aged 25. The Andhra Pradesh Children and Parents Study started with over 2,500 children born in India between 1987 and 1990 and has followed them up three times up to the age of 25. I will examine each study separately and then compare the findings to see if they are alike or different. This will help me to find out if my findings are consistent in these two very different populations. By identifying when in life the gender differences we see in older adults actually start, we can identify times when programs to prevent them might be effective. By identifying the reasons behind any gender differences, effective gender-specific programs and interventions can be delivered early in life to prevent gender differences later in life.
心脏病和糖尿病是全球和英国男性和女性死亡的主要原因。成人糖尿病存在性别差异。例如,糖尿病在男性中比在女性中更常见。平均而言,超重或肥胖男性患糖尿病的脂肪水平也低于超重或肥胖女性。然而,一旦女性患上糖尿病,她比男性糖尿病患者更容易患心脏病。我们知道,一个人患糖尿病和心脏病的风险在童年时期就开始形成。即使在幼儿中,血液中的糖和其他物质的水平也可以告诉我们他们成年后患糖尿病的风险。该项目的目的是查明男性和女性在以后的糖尿病和心脏病风险方面是否存在明显的差异,这一差异在男孩和女孩中从出生一直到童年直至成年早期都已经很明显。我将通过比较男孩和女孩从出生到年轻时血液中糖和其他物质的含量来做到这一点。我将调查超重或肥胖的年轻男孩血液中的糖含量是否与超重或肥胖的年轻女孩相同。这将告诉我们,与超重或肥胖的女孩相比,超重或肥胖的男孩是否已经表现出更高的患糖尿病的机会。我还将调查血液中糖分和其他物质含量高的女孩与血液中糖分和其他物质含量高的男孩相比,她们的心脏是否有问题。这将告诉我们,在血液中糖分和其他与糖尿病有关的物质含量较高的年轻女孩的心脏中,是否已经可以检测到糖尿病女性在晚年患心脏病的风险较高。然后我将调查任何差异背后的原因;吸烟或体力活动等不同的行为模式、激素等生物因素或反映不同脂肪储存模式的体形差异是否可以解释这些差异。我将使用两项不同研究的数据,这些研究跟踪参与者从出生到童年到成年的整个过程。雅芳家长和儿童纵向研究于 1991/1992 年开始,对布里斯托尔的 14,000 多名孕妇进行了跟踪调查,她们的孩子现在已经 25 岁了。安得拉邦儿童和家长研究开始于 1987 年至 1990 年间在印度出生的 2,500 多名儿童,并对他们进行了 3 次跟踪调查,直至 25 岁。我将分别检查每项研究,然后比较的结果,看看它们是否相同或不同。这将帮助我查明我的发现在这两个截然不同的人群中是否一致。通过确定我们在老年人中看到的性别差异在生活中何时真正开始,我们可以确定预防这些差异的计划可能有效的时间。通过找出性别差异背后的原因,可以在生命早期实施有效的针对特定性别的计划和干预措施,以防止以后生活中的性别差异。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Epigenetic gestational age and trajectories of weight and height during childhood: a prospective cohort study
- DOI:10.1186/s13148-019-0761-7
- 发表时间:2019-12-16
- 期刊:
- 影响因子:5.7
- 作者:Bright, Harold D.;Howe, Laura D.;O'Keeffe, Linda M.
- 通讯作者:O'Keeffe, Linda M.
Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics
四个生命阶段心脏代谢特征的性别差异:重复代谢组学的队列研究
- DOI:10.1101/2020.01.15.19015206
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Bell J
- 通讯作者:Bell J
Body Mass Index in Children Validated by Metabolic and Fat Mass Profiling
通过代谢和脂肪量分析验证儿童体重指数
- DOI:10.1016/j.jacc.2018.10.016
- 发表时间:2018
- 期刊:
- 影响因子:24
- 作者:Mäkinen V
- 通讯作者:Mäkinen V
Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children
儿童阿尔茨海默病的多基因风险评分和心脏代谢危险因素的轨迹
- DOI:10.1101/580548
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Korologou-Linden R
- 通讯作者:Korologou-Linden R
Additional file 1 of Puberty timing and markers of cardiovascular structure and function at 25 years: a prospective cohort study
补充文件 1:青春期时间和 25 岁时心血管结构和功能的标志物:一项前瞻性队列研究
- DOI:10.6084/m9.figshare.14299593
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Maher G
- 通讯作者:Maher G
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Linda O' Keeffe其他文献
Linda O' Keeffe的其他文献
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