The influence of Executive Function on Mental Health in vulnerable adolescents: a multi-site low and middle income country approach
执行功能对弱势青少年心理健康的影响:多地点低收入和中等收入国家方法
基本信息
- 批准号:MC_PC_MR/R019606/1
- 负责人:
- 金额:$ 24.93万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2018
- 资助国家:英国
- 起止时间:2018 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Executive function (EF) regulates emotions, thoughts and behaviours, and difficulties in EF have been strongly implicated in mental health problems in high income countries (HICs). EF includes a set of cognitive skills such as working memory, cognitive flexibility, selective attention and inhibition which form the building blocks for higher order cognitive functions such as reasoning, planning every day activities and problem solving. EF is therefore critical in emotional, behavioural, cognitive, and social functioning and interpersonal relationships. Poor EF has wide ranging implications in a number of important areas; in particular, it is associated with increased rates of mental health disorders such as depression, anxiety and attention deficit hyperactivity disorder. There are two periods during which development of EF is rapid; childhood and adolescence. These are critical time points to intervene and prevent impairments in EF.Poor EF can result from biomedical factors, such as poor nutrition or exposure to HIV and malaria or from exposure to poverty, particularly when this occurs during periods of rapid EF development. These risk factors will affect both individuals' performance on EF tasks as well as the neural substrates of EF. The high level of socioeconomic adversity and the presence of multiple risk factors will have a strong influence on adolescents' achieving their potential and will impact their contributions to society through employment, social functioning, mental and physical health. Investigators across multiple Departments at the University of Oxford have over a number of years concentrated on the relationship between EF, mental health and risk taking behaviours such as (unprotected sex, alcohol or drug use). Research in this area is being carried out in collaboration with investigators in multiple Low and Middle Income Countries (LMIC): by Abubakar and Newton in Kenya; Kahn, Scerif, Demeyere and Stein in South Africa; Favara, Sanchez and Pankhurst in Ethiopia and Peru. This proposal will create a platform for UK and LMIC researchers working on EF and mental health, the harmonisation of EF tools currently used across sites and it will enable the piloting of a new EF measure to allow for the comparison of EF and its association with mental health data across sites. A number of studies have shown that EF can be improved in children and adolescents either through direct stimulation (e.g. EF-specific training tasks) or through enhancing their psychosocial environment, but not all these interventions may be financially viable or culturally acceptable in LMICs. A necessary step before intervening is to ensure we have accurate tools which reliably measure EF across settings and cultures, and that the cultural acceptability of relevant interventions is assessed.As part of this proposal, we will refine our measurement tools and investigate contextually appropriate interventions to improve EF, during one of the critical periods of EF development i.e. adolescence. Improving EF in adolescence will ensure they will be able to take advantage of school education and it will allow for informed relational and occupational choices, as well as reduce the risk of high-risk sexual and substance use behaviours and promote physical and mental health.
执行功能(EF)调节情绪,思想和行为,EF的困难与高收入国家(HIC)的心理健康问题密切相关。EF包括一系列认知技能,如工作记忆、认知灵活性、选择性注意和抑制,这些技能构成了推理、计划日常活动和解决问题等高级认知功能的基石。因此,EF在情感,行为,认知和社会功能以及人际关系中至关重要。EF差在许多重要领域具有广泛的影响;特别是,它与抑郁症,焦虑症和注意力缺陷多动障碍等心理健康障碍的发病率增加有关。有两个时期,EF的发展是迅速的:儿童和青少年。这些都是关键的时间点,干预和预防EF的损害。EF差可能是由于生物医学因素,如营养不良或暴露于艾滋病毒和疟疾或暴露于贫困,特别是当这发生在EF快速发展的时期。这些危险因素会影响个体在执行功能任务上的表现以及执行功能的神经基质。严重的社会经济困境和多种风险因素的存在将对青少年实现其潜力产生重大影响,并将影响他们通过就业、社会功能、身心健康对社会的贡献。牛津大学多个部门的研究人员多年来一直专注于EF,心理健康和冒险行为之间的关系,例如(无保护的性行为,酒精或药物使用)。这一领域的研究正在与多个中低收入国家的调查人员合作进行:肯尼亚的Abubakar和Newton;南非的Kahn、Scerif、Demeyere和Stein;埃塞俄比亚和秘鲁的Favara、Sanchez和Pankhurst。该提案将为英国和LMIC研究EF和心理健康的研究人员创建一个平台,协调目前在各研究中心使用的EF工具,并将使新EF措施的试点能够比较EF及其与各研究中心心理健康数据的关联。许多研究表明,儿童和青少年的EF可以通过直接刺激(例如EF特定的培训任务)或通过改善他们的心理社会环境来改善,但并非所有这些干预措施在低收入国家都是经济上可行或文化上可接受的。干预前的一个必要步骤是确保我们有准确的工具,可以可靠地测量不同环境和文化的EF,并评估相关干预措施的文化可接受性。作为这一建议的一部分,我们将改进我们的测量工具,并调查在EF发展的关键时期之一,即青春期,适当的干预措施,以提高EF。改善青少年的EF将确保他们能够利用学校教育,并允许知情的关系和职业选择,以及减少高风险性行为和药物使用行为的风险,并促进身心健康。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Prevalence, risk and protective indicators of common mental disorders among young people living with HIV compared to their uninfected peers from the Kenyan coast: a cross-sectional study.
- DOI:10.1186/s12888-021-03079-4
- 发表时间:2021-02-10
- 期刊:
- 影响因子:4.4
- 作者:Nyongesa MK;Mwangi P;Kinuthia M;Hassan AS;Koot HM;Cuijpers P;Newton CRJC;Abubakar A
- 通讯作者:Abubakar A
HIV virological non-suppression is highly prevalent among 18- to 24-year-old youths on antiretroviral therapy at the Kenyan coast.
在肯尼亚海岸的抗逆转录病毒疗法中,在18至24岁的年轻人中,HIV病毒学非抑制非常普遍。
- DOI:10.1186/s12879-022-07428-w
- 发表时间:2022-05-11
- 期刊:
- 影响因子:3.7
- 作者:Nyongesa, Moses K.;Mwatasa, Mwaganyuma H.;Kagonya, Vincent A.;Mwambingu, Gabriel;Ngetsa, Caroline;Newton, Charles R. J. C.;Abubakar, Amina
- 通讯作者:Abubakar, Amina
Health Risk Behaviour among Adolescents Living with HIV in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.
- DOI:10.1155/2018/7375831
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:Ssewanyana D;Mwangala PN;van Baar A;Newton CR;Abubakar A
- 通讯作者:Abubakar A
Correlates of health-related quality of life in primary caregivers of perinatally HIV infected and HIV exposed uninfected adolescents at the Kenyan Coast.
- DOI:10.1186/s12955-022-01915-z
- 发表时间:2022-01-21
- 期刊:
- 影响因子:3.6
- 作者:Mwangala PN;Ssewanyana D;Mwangi P;Chongwo E;Nasambu C;Kagonya VA;Scerif G;Newton CR;Abubakar A
- 通讯作者:Abubakar A
Clustering of health risk behaviors among adolescents in Kilifi, Kenya, a rural Sub-Saharan African setting.
- DOI:10.1371/journal.pone.0242186
- 发表时间:2020
- 期刊:
- 影响因子:3.7
- 作者:Ssewanyana D;Abubakar A;Newton CRJC;Otiende M;Mochamah G;Nyundo C;Walumbe D;Nyutu G;Amadi D;Doyle AM;Ross DA;Nyaguara A;Williams TN;Bauni E
- 通讯作者:Bauni E
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Charles Newton其他文献
Improving measurement and prediction in personnel selection through the application of machine learning
通过机器学习的应用改进人员选拔的测量和预测
- DOI:
10.1111/peps.12608 - 发表时间:
2023 - 期刊:
- 影响因子:5.5
- 作者:
Nick Koenig;Scott Tonidandel;I. Thompson;Betsy H. Albritton;Farshad Koohifar;Georgi P. Yankov;Andrew Speer;Jay H. Hardy;Carter Gibson;Chris Frost;Mengqiao Liu;Denver McNeney;John Capman;Shane Lowery;M. Kitching;Anjali Nimbkar;Anthony Boyce;Tianjun Sun;Feng Guo;Hanyi Min;Bo Zhang;Logan Lebanoff;Henry Phillips;Charles Newton - 通讯作者:
Charles Newton
An expansion of the phenotype in individuals with SYNCRIP-Related Neurodevelopmental Disorder
- DOI:
10.1016/j.rare.2024.100052 - 发表时间:
2024-01-01 - 期刊:
- 影响因子:
- 作者:
Tooba Shafiq;Joanna L. Feng;Lindsay Phillips;Kara Murias;Marcia Ferguson;Kristin Baranano;Alaina Acchione;Patricia Kipkemoi;Collins Kipkoech;Eunice Chepkemoi;Amina Abubakar;Charles Newton;Celia van der Merwe;Emily O’Heir;Alice Galvin;Aixa Gonzalez Garcia;Alisha D’Souza;Jennifer Stefanich;Amelle Shillington;Annabelle Tuttle - 通讯作者:
Annabelle Tuttle
56. GENOME WIDE ASSOCIATION STUDY OF SCHIZOPHRENIA IN THE NEUROPSYCHIATRIC GENETICS IN AFRICAN POPULATION-PSYCHOSIS (NEUROGAP-PSYCHOSIS) STUDY
非洲人群精神神经遗传学中精神分裂症的全基因组关联研究——精神病(神经间隙-精神病)研究
- DOI:
10.1016/j.euroneuro.2024.08.170 - 发表时间:
2024-10-01 - 期刊:
- 影响因子:6.700
- 作者:
Lerato Majara;Toni Boltz;Dickens Akena;Lukoye Atwoli;Bizu Gelaye;Symon Kariuki;Charles Newton;Dan Stein;Anne Stevenson;Rocky Stroud;Karestan Koenen;Solomon Teferra;Zukiswa Zingela;Alicia Martin - 通讯作者:
Alicia Martin
P523: The NeuroDev Study: Genetic characterization of neurodevelopmental disorders in African populations
- DOI:
10.1016/j.gimo.2023.100570 - 发表时间:
2023-01-01 - 期刊:
- 影响因子:
- 作者:
Emily O'Heir;Patricia Kipkemoi;Heesu Ally Kim;Bjorn Christ;Emma Eastman;Celia van der Merwe;Alice Galvin;Jake Allen;Victoria de Menil;Alysia Lovgren;Christina Austin-Tse;Amina Abubakar;Charles Newton;Kirsten Donald;Anne O'Donnell-Luria;Elise Robinson - 通讯作者:
Elise Robinson
PHENOTYPING WITH THE NEUROPSYCHIATRIC GENETICS OF AFRICAN POPULATIONS-PSYCHOSIS (NEUROGAP-PSYCHOSIS) STUDY
- DOI:
10.1016/j.euroneuro.2022.07.055 - 发表时间:
2022-10-01 - 期刊:
- 影响因子:
- 作者:
Bizu Gelaye;Amantia Ametaj;Dickens Akena;Lukoye Atwoli;Symon Kariuki;Charles Newton;Solomon Teferra;Dan Stein;Zukiswa Zingela;Kristina Korte;Anne Stevenson;Rocky Stroud;Kristianna Post;Lori Chibnik;Karestan Koenen - 通讯作者:
Karestan Koenen
Charles Newton的其他文献
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{{ truncateString('Charles Newton', 18)}}的其他基金
Parenteral interventions to support families of children with neurodisability in low resource settings
肠外干预以支持资源匮乏地区神经障碍儿童的家庭
- 批准号:
MR/N022157/1 - 财政年份:2016
- 资助金额:
$ 24.93万 - 项目类别:
Research Grant
Abubakar;Pwani;Adolescent Executive Functioning Association with Scholastic Outcomes, Risk Taking Behavior and Medical Adherence in the Context of HIV
Abubakar;Pwani;艾滋病毒背景下青少年执行功能与学业成绩、冒险行为和医疗依从性的关系
- 批准号:
MR/M025454/1 - 财政年份:2016
- 资助金额:
$ 24.93万 - 项目类别:
Research Grant
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