ACTG 240--TRIAL OF ZDV VS 2',3' DIDEHYDRO 3' D4T IN CHILDREN WITH HIV INFECTION

ACTG 240--ZDV 与 2,3 二氢 3 D4T 在 HIV 感染儿童中的试验

• 批准号: 5224952
• 负责人: RUSSELL B. VAN DYKE
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5224952
• 关键词: 2'3' dideoxynucleoside; clinical research; clinical trials; combination chemotherapy; drug screening /evaluation; human subject; human therapy evaluation; oral administration; pediatric AIDS; pharmacokinetics; preschool child (1-5); zidovudine

A study to compare the relative safety and tolerance of orally administered ZDV and D4T in symptomatic HIV-infected children aged 90 days to 6 years. The study also compares the clinical, virologic and immunologic effects of ZDV and d4T monotherapy and will obtain population pharmacokinetic parameters for both drugs.

一项比较口服药物相对安全性和耐受性的研究 对 90 岁有症状的 HIV 感染儿童施用 ZDV 和 D4T 天到6年。 该研究还比较了临床、病毒学和 ZDV 和 d4T 单一疗法的免疫学效果并将获得人群 两种药物的药代动力学参数。