MRC-PHE Centre for Environment and Health post-doctoral fellowship programme.

MRC-PHE 环境与健康中心博士后奖学金计划。

• 批准号: MR/M501669/1
• 负责人: Paul Elliott
• 金额: $ 202.39万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM501669%2F1
• 关键词: MRC; PHE; Centre; Environment; Health

"The environmental sciences are at the brink of a new era in which investigators move from using relatively crude estimate of exposure (e.g., distance based methods, questionnaires, diaries) to sophisticated modelling techniques, biomarkers and personalised 24h measures of exposure from a range of hazards. This advance through the utilisation of high-throughput omic technologies, new miniaturised exposure sensors and application of advanced hybrid exposure models across the lifecourse will be a central focus of the Centre's activity over the next 5 years.As we move to the next phase of Centre funding we will take advantage of the increasingly rich metadata that are available for our cohorts and we will link these with primary care data records as they become available through the CPRD network. We will further exploit the rich and unique data resources available to Centre researchers afforded by the UK Small Area Health Statistics Unit (SAHSU) at Imperial College and the Environmental Research Group (ERG) at King's College, and utilise the improved exposure assessment methods and application of omic technologies for a more integrated approach to environmental health research. This approach across our work programmes will allow us to focus activity around a conceptual framework that examines links from the molecular level through man to populations across the lifecourse and provide outputs to advance understanding and better inform environment and health policy."

“环境科学正处于一个新时代的边缘，在这个新时代中，调查人员从使用相对粗略的暴露估计（例如，从基于距离的方法、问卷调查、日记）到复杂的建模技术、生物标志物和一系列危害暴露的个性化24小时测量。通过利用高通量组学技术，在未来5年内，新的嵌入式曝光传感器和在整个生命过程中应用先进的混合曝光模型将是中心活动的中心重点。随着我们进入中心资助的下一阶段，我们将利用越来越丰富的元数据，为我们的队列，我们将这些与初级保健数据记录相关联因为它们可以通过CPRD网络获得。我们将进一步利用丰富和独特的数据资源提供给中心的研究人员由英国小区域健康统计单位（SAHSU）在帝国理工学院和环境研究小组（ERG）在国王学院，并利用改进的暴露评估方法和组学技术的应用，为环境健康研究提供更综合的方法。在我们的工作方案中采取这种做法，将使我们能够围绕一个概念框架开展活动，该框架审查从分子水平到人到整个生命周期的人口之间的联系，并提供产出，以促进理解，更好地为环境和卫生政策提供信息。"

项目成果

Contributions of event rates, pre-hospital deaths, and deaths following hospitalisation to variations in myocardial infarction mortality in 326 districts in England: a spatial analysis of linked hospitalisation and mortality data.

• DOI: 10.1016/s2468-2667(22)00108-6
• 发表时间: 2022-10
• 期刊: The Lancet. Public health
• 作者: Asaria P;Bennett JE;Elliott P;Rashid T;Iyathooray Daby H;Douglass M;Francis DP;Fecht D;Ezzati M
• 通讯作者: Ezzati M

Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth.

• DOI: 10.1186/s12916-022-02685-7
• 发表时间: 2023-01-11
• 期刊: BMC MEDICINE
• 影响因子: 9.3
• 作者: Alfano, Rossella;Zugna, Daniela;Barros, Henrique;Bustamante, Mariona;Chatzi, Leda;Ghantous, Akram;Herceg, Zdenko;Keski-Rahkonen, Pekka;de Kok, Theo M.;Nawrot, Tim S.;Relton, Caroline L.;Robinson, Oliver;Roumeliotaki, Theano;Scalbert, Augustin;Vrijheid, Martine;Vineis, Paolo;Richiardi, Lorenzo;Plusquin, Michelle
• 通讯作者: Plusquin, Michelle

A Bayesian mixture modeling approach for public health surveillance.

• DOI: 10.1093/biostatistics/kxy038
• 发表时间: 2020-07-01
• 期刊: Biostatistics (Oxford, England)
• 作者: Boulieri A;Bennett JE;Blangiardo M
• 通讯作者: Blangiardo M

Spatio-temporal model to estimate life expectancy and to detect unusual trends at the local authority level in England.

• DOI: 10.1136/bmjopen-2020-036855
• 发表时间: 2020-11-12
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Boulieri A;Blangiardo M
• 通讯作者: Blangiardo M

Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight.

• DOI: 10.1038/s41366-022-01108-0
• 发表时间: 2022-07
• 期刊: INTERNATIONAL JOURNAL OF OBESITY
• 影响因子: 4.9
• 作者: Alfano, Rossella;Plusquin, Michelle;Robinson, Oliver;Brescianini, Sonia;Chatzi, Lida;Keski-Rahkonen, Pekka;Handakas, Evangelos;Maitre, Lea;Nawrot, Tim;Robinot, Nivonirina;Roumeliotaki, Theano;Sassi, Franco;Scalbert, Augustin;Vrijheid, Martine;Vineis, Paolo;Richiardi, Lorenzo;Zugna, Daniela
• 通讯作者: Zugna, Daniela