MRC-PHE Centre for Environment and Health post-doctoral fellowship programme.

“环境科学正处于一个新时代的边缘，在这个时代，研究人员从使用相对粗糙的暴露估计（例如，基于距离的方法，问卷调查，日记）转向复杂的建模技术，生物标志物和个性化的24小时暴露于一系列危害的测量。通过利用高通量基因组技术、新型小型化暴露传感器和应用先进的混合暴露模型，这一进步将成为该中心未来5年活动的核心重点。当我们进入中心资助的下一阶段时，我们将利用可供我们的队列使用的日益丰富的元数据，并将这些元数据与通过CPRD网络提供的初级保健数据记录联系起来。我们将进一步利用帝国理工学院的英国小区域卫生统计单位（SAHSU）和国王学院的环境研究小组（ERG）为中心研究人员提供的丰富而独特的数据资源，并利用改进的暴露评估方法和基因组学技术的应用，对环境健康研究采取更综合的方法。在我们的工作方案中采用这种方法将使我们能够围绕一个概念框架开展活动，该框架审查从分子水平到人到整个生命过程中的人群的联系，并提供产出，以促进理解并更好地为环境和卫生政策提供信息。”

"The environmental sciences are at the brink of a new era in which investigators move from using relatively crude estimate of exposure (e.g., distance based methods, questionnaires, diaries) to sophisticated modelling techniques, biomarkers and personalised 24h measures of exposure from a range of hazards. This advance through the utilisation of high-throughput omic technologies, new miniaturised exposure sensors and application of advanced hybrid exposure models across the lifecourse will be a central focus of the Centre's activity over the next 5 years.As we move to the next phase of Centre funding we will take advantage of the increasingly rich metadata that are available for our cohorts and we will link these with primary care data records as they become available through the CPRD network. We will further exploit the rich and unique data resources available to Centre researchers afforded by the UK Small Area Health Statistics Unit (SAHSU) at Imperial College and the Environmental Research Group (ERG) at King's College, and utilise the improved exposure assessment methods and application of omic technologies for a more integrated approach to environmental health research. This approach across our work programmes will allow us to focus activity around a conceptual framework that examines links from the molecular level through man to populations across the lifecourse and provide outputs to advance understanding and better inform environment and health policy."