REACT Long COVID (REACT-LC)

有些COVID-19患者会出现数周或数月的症状（长期COVID），而其他人则会出现短期疾病或没有症状。我们对为什么会发生这种情况知之甚少。大多数关于长期COVID的研究都是针对住院患者的。我们的研究将涉及社区中参加过导致COVID-19的病毒的REACT研究的人。来自REACT的3万多人的检测结果呈阳性，他们加上9万名检测结果呈阴性的样本，将被邀请参加这项新研究。这12万人将收到一份关于他们自测试以来的健康、症状和经历的调查;我们还将链接到健康记录。长期COVID的参与者将被要求加入一个小组，定期提供有关其症状的最新信息; 60人将被邀请进行深入访谈。我们将在18个月后重复对12万人的调查，以跟踪症状和健康状况。我们将与一个公共顾问小组密切合作，包括长期COVID患者，以制定一套反映最重要症状的患者报告结果。我们还将邀请多达8，000名检测呈阳性的人，其中包括至少4，000名长期感染新冠病毒的人，前往评估中心进行健康检测并采集样本以检测遗传和其他生物标志物。大约2,000人将在4-6个月后参加随访，进行重复测量和采样。这些研究的数据将被分析，以找出影响为什么有些人得了Long COVID而另一些人没有的因素。生物学研究将帮助我们了解导致持续症状的机制，并可能指出可能的治疗方法。通过调查和与参与者的合作，我们将了解为什么有些人更脆弱，以及如何最好地支持他们。

Some people with COVID-19 experience symptoms for several weeks or months (Long COVID), while others have a short illness or no symptoms. We have very little understanding of why this happens. Most research on Long COVID has been with hospitalised patients. Our study will involve people in the community who have taken part in the REACT study of the virus that causes COVID-19. Over 30,000 people from REACT have had positive test results and they, plus a sample of 90,000 who tested negative, will be invited to take part in the new study. These 120,000 people will be sent a survey about their health, symptoms and experiences since the test; we will also link to health records. Participants with Long COVID will be asked to join a panel to provide regular updates on their symptoms; 60 will be invited for in-depth interview. We will repeat the survey of the 120,000 after 18 months to track symptoms and their health. We will work closely with a panel of public advisers including people with Long COVID to develop a set of patient-reported outcomes that reflect the symptoms that are most important. We will also invite up to 8,000 people with positive tests, including at least 4,000 with Long COVID, to an assessment centre for health tests and samples to test for genetic and other biological markers. Around 2,000 will attend a follow-up visit after 4-6 months for repeated measurements and samples. The data from these studies will be analysed to find factors affecting why some people get Long COVID and others don’t. The biological studies will help us understand mechanisms causing persistent symptoms and may point to possible treatments. Through the surveys and work with participants we will understand why some people are more vulnerable and how best to support them.