The Airwave Health Monitoring Study (AHMS). An Occupational Cohort Study of the British Police Forces.

Airwave 健康监测研究 (AHMS)。

• 批准号: MR/R023484/1
• 负责人: Paul Elliott
• 金额: $ 253.43万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FR023484%2F1
• 关键词: Airwave; Health; Monitoring; Study; AHMS

Police officers are among one of the occupational groups presenting with higher rates of ill health compared to other workers and are exposed to a wide range of chemical, physical and psychosocial risk factors that can affect their health and performance at work. This raises questions about how the risk factors they face at work affects their performance and ultimately their wellbeing and safety, as well as the safety of the public. Recent staff surveys and literature have indicated that mental health issues, such as anxiety and depression, are also a particular concern. Understanding these hazards and risks to police officer health and putting tailored safety and health promotion measures in place is an obvious solution. However, there is a lack of detailed information on the specific factors involved and the how these, individually or in combination, affect health. It is also likely that health outcomes vary according to workplace factors (e.g. region, rank, hours worked) but also vary according to individual make-up and sociodemographic characteristics. Therefore, understanding and quantifying risk factors to police officer health may impact on the health and wellbeing of the individual, their colleagues and families as well as on the health of the public. The Airwave Health Monitoring Study (AHMS) was established to evaluate possible health risks associated with the use of the digital communication system used by the police forces and other emergency services. It is a large (over 50,000 participants) long-term study investigating the health of police officers and staff across Great Britain. Currently, follow-up measures are being undertaken in England only. Our objectives are both to extend the follow-up of the AHMS to Scotland and Wales, and to provide a resource for studying how gender, lifestyle, and occupational exposures interact with genetic and metabolic factors in relation to physical and mental health, in a comparatively young working population with a high representation of men.Specifically we plan to: i) follow-up the Scottish and Welsh AHMS participants who attended a baseline clinical assessment (N = 13,681) approximately 7.5 years later; ii) develop a method to estimate exposures to a range of chemical, physical and psychosocial risk factors to health by combining group level data through a bespoke Job Exposure Matrix (JEM) and individual level data to refine and evaluate JEM performance.iii) use mental health as an exemplar case study to examine the relationships between work-related risk factors and mental health difficulties, and identify the individual and/or workplace 'protective' factors that promote wellbeing within the workplace.Our proposal has high policy relevance at the level of both government and employers. It represents a novel, cross-sectoral collaboration between academics across five UK leading universities and in partnership with police forces and the Police Federation (representing rank and file officers) across Great Britain. The application has wide support from our stakeholders who have been included in the project from the outset in order to ensure that the findings are translated into interventions that impact on health and wellbeing.

与其他工人相比，警察是健康状况不佳率较高的职业群体之一，他们面临着各种各样的化学、物理和心理社会风险因素，这些因素可能影响他们的健康和工作表现。这就提出了他们在工作中面临的风险因素如何影响他们的表现，最终影响他们的福祉和安全以及公众的安全的问题。最近的工作人员调查和文献表明，焦虑和抑郁等心理健康问题也是一个特别令人关切的问题。了解这些对警察健康的危害和风险，并制定有针对性的安全和健康促进措施，显然是一个解决办法。然而，缺乏关于所涉具体因素以及这些因素如何单独或共同影响健康的详细资料。健康结果也可能因工作场所因素（如地区、级别、工作时间）而异，但也因个人构成和社会人口特征而异。因此，了解和量化警官健康的风险因素可能会影响个人、同事和家人的健康和福祉，以及公众的健康。空气波健康监测研究（AHMS）的建立是为了评估与警察部队和其他紧急服务使用的数字通信系统相关的可能的健康风险。这是一项大型（超过50，000名参与者）长期研究，调查英国各地警察和工作人员的健康状况。目前，仅在英格兰采取了后续措施。我们的目标是将AHMS的后续行动扩展到苏格兰和威尔士，并为研究性别、生活方式和职业暴露如何与遗传和代谢因素相互作用提供资源，这些因素与身体和精神健康有关，在相对年轻的工作人口中，男性占很大比例。具体而言，我们计划：i）跟踪参加基线临床评估的苏格兰和威尔士AHMS参与者（N = 13，681）约7.5年后;（二）制定一种方法，通过定制的工作接触矩阵（JEM）结合群体层面的数据，和个人层面的数据，以完善和评估JEM的表现。iii）使用心理健康作为一个典型的案例研究，以检查与工作有关的风险因素和心理健康困难之间的关系，并确定个人和/或工作场所的“保护”因素，促进工作场所内的福祉。我们的建议在政府和雇主它代表了英国五所顶尖大学的学者之间的一种新颖的跨部门合作，并与英国各地的警察部队和警察联合会（代表普通警察）建立了伙伴关系。该应用程序得到了我们的利益相关者的广泛支持，他们从一开始就参与了该项目，以确保研究结果转化为对健康和福祉产生影响的干预措施。

项目成果

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

• DOI: 10.1038/s41467-018-04362-x
• 发表时间: 2018-05-29
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Davies G;Lam M;Harris SE;Trampush JW;Luciano M;Hill WD;Hagenaars SP;Ritchie SJ;Marioni RE;Fawns-Ritchie C;Liewald DCM;Okely JA;Ahola-Olli AV;Barnes CLK;Bertram L;Bis JC;Burdick KE;Christoforou A;DeRosse P;Djurovic S;Espeseth T;Giakoumaki S;Giddaluru S;Gustavson DE;Hayward C;Hofer E;Ikram MA;Karlsson R;Knowles E;Lahti J;Leber M;Li S;Mather KA;Melle I;Morris D;Oldmeadow C;Palviainen T;Payton A;Pazoki R;Petrovic K;Reynolds CA;Sargurupremraj M;Scholz M;Smith JA;Smith AV;Terzikhan N;Thalamuthu A;Trompet S;van der Lee SJ;Ware EB;Windham BG;Wright MJ;Yang J;Yu J;Ames D;Amin N;Amouyel P;Andreassen OA;Armstrong NJ;Assareh AA;Attia JR;Attix D;Avramopoulos D;Bennett DA;Böhmer AC;Boyle PA;Brodaty H;Campbell H;Cannon TD;Cirulli ET;Congdon E;Conley ED;Corley J;Cox SR;Dale AM;Dehghan A;Dick D;Dickinson D;Eriksson JG;Evangelou E;Faul JD;Ford I;Freimer NA;Gao H;Giegling I;Gillespie NA;Gordon SD;Gottesman RF;Griswold ME;Gudnason V;Harris TB;Hartmann AM;Hatzimanolis A;Heiss G;Holliday EG;Joshi PK;Kähönen M;Kardia SLR;Karlsson I;Kleineidam L;Knopman DS;Kochan NA;Konte B;Kwok JB;Le Hellard S;Lee T;Lehtimäki T;Li SC;Lill CM;Liu T;Koini M;London E;Longstreth WT Jr;Lopez OL;Loukola A;Luck T;Lundervold AJ;Lundquist A;Lyytikäinen LP;Martin NG;Montgomery GW;Murray AD;Need AC;Noordam R;Nyberg L;Ollier W;Papenberg G;Pattie A;Polasek O;Poldrack RA;Psaty BM;Reppermund S;Riedel-Heller SG;Rose RJ;Rotter JI;Roussos P;Rovio SP;Saba Y;Sabb FW;Sachdev PS;Satizabal CL;Schmid M;Scott RJ;Scult MA;Simino J;Slagboom PE;Smyrnis N;Soumaré A;Stefanis NC;Stott DJ;Straub RE;Sundet K;Taylor AM;Taylor KD;Tzoulaki I;Tzourio C;Uitterlinden A;Vitart V;Voineskos AN;Kaprio J;Wagner M;Wagner H;Weinhold L;Wen KH;Widen E;Yang Q;Zhao W;Adams HHH;Arking DE;Bilder RM;Bitsios P;Boerwinkle E;Chiba-Falek O;Corvin A;De Jager PL;Debette S;Donohoe G;Elliott P;Fitzpatrick AL;Gill M;Glahn DC;Hägg S;Hansell NK;Hariri AR;Ikram MK;Jukema JW;Vuoksimaa E;Keller MC;Kremen WS;Launer L;Lindenberger U;Palotie A;Pedersen NL;Pendleton N;Porteous DJ;Räikkönen K;Raitakari OT;Ramirez A;Reinvang I;Rudan I;Dan Rujescu;Schmidt R;Schmidt H;Schofield PW;Schofield PR;Starr JM;Steen VM;Trollor JN;Turner ST;Van Duijn CM;Villringer A;Weinberger DR;Weir DR;Wilson JF;Malhotra A;McIntosh AM;Gale CR;Seshadri S;Mosley TH Jr;Bressler J;Lencz T;Deary IJ
• 通讯作者: Deary IJ

Lifestyle Score and Risk of Hypertension in the Airwave Health Monitoring Study of British Police Force Employees.

在英国警察部队的Airwave健康监测研究中，生活方式评分和高血压风险。

• DOI: 10.3390/ijerph20054029
• 发表时间: 2023-02-24
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Aljuraiban, Ghadeer S;Gibson, Rachel;Chan, Doris S M;Elliott, Paul;Chan, Queenie;Griep, Linda M Oude
• 通讯作者: Griep, Linda M Oude

Finding Correspondence between Metabolomic Features in Untargeted Liquid Chromatography-Mass Spectrometry Metabolomics Datasets.

• DOI: 10.1021/acs.analchem.1c03592
• 发表时间: 2022-04-12
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Pinto, Rui Climaco;Karaman, Ibrahim;Lewis, Matthew R.;Hallqvist, Jenny;Kaluarachchi, Manuja;Graca, Goncalo;Chekmeneva, Elena;Durainayagam, Brenan;Ghanbari, Mohsen;Ikram, M. Arfan;Zetterberg, Henrik;Griffin, Julian;Elliott, Paul;Tzoulaki, Ioanna;Dehghan, Abbas;Herrington, David;Ebbels, Timothy
• 通讯作者: Ebbels, Timothy

Acceptability, Usability, and Performance of Lateral Flow Immunoassay Tests for Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies: REACT-2 Study of Self-Testing in Nonhealthcare Key Workers.

• DOI: 10.1093/ofid/ofab496
• 发表时间: 2021-11
• 期刊: Open forum infectious diseases
• 影响因子: 4.2
• 作者: Davies B;Araghi M;Moshe M;Gao H;Bennet K;Jenkins J;Atchison C;Darzi A;Ashby D;Riley S;Barclay W;Elliott P;Ward H;Cooke G
• 通讯作者: Cooke G

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.

• DOI: 10.1038/s41380-020-0719-3
• 发表时间: 2021-06
• 期刊: Molecular psychiatry
• 影响因子: 11
• 作者: de Las Fuentes L;Sung YJ;Noordam R;Winkler T;Feitosa MF;Schwander K;Bentley AR;Brown MR;Guo X;Manning A;Chasman DI;Aschard H;Bartz TM;Bielak LF;Campbell A;Cheng CY;Dorajoo R;Hartwig FP;Horimoto ARVR;Li C;Li-Gao R;Liu Y;Marten J;Musani SK;Ntalla I;Rankinen T;Richard M;Sim X;Smith AV;Tajuddin SM;Tayo BO;Vojinovic D;Warren HR;Xuan D;Alver M;Boissel M;Chai JF;Chen X;Christensen K;Divers J;Evangelou E;Gao C;Girotto G;Harris SE;He M;Hsu FC;Kühnel B;Laguzzi F;Li X;Lyytikäinen LP;Nolte IM;Poveda A;Rauramaa R;Riaz M;Rueedi R;Shu XO;Snieder H;Sofer T;Takeuchi F;Verweij N;Ware EB;Weiss S;Yanek LR;Amin N;Arking DE;Arnett DK;Bergmann S;Boerwinkle E;Brody JA;Broeckel U;Brumat M;Burke G;Cabrera CP;Canouil M;Chee ML;Chen YI;Cocca M;Connell J;de Silva HJ;de Vries PS;Eiriksdottir G;Faul JD;Fisher V;Forrester T;Fox EF;Friedlander Y;Gao H;Gigante B;Giulianini F;Gu CC;Gu D;Harris TB;He J;Heikkinen S;Heng CK;Hunt S;Ikram MA;Irvin MR;Kähönen M;Kavousi M;Khor CC;Kilpeläinen TO;Koh WP;Komulainen P;Kraja AT;Krieger JE;Langefeld CD;Li Y;Liang J;Liewald DCM;Liu CT;Liu J;Lohman KK;Mägi R;McKenzie CA;Meitinger T;Metspalu A;Milaneschi Y;Milani L;Mook-Kanamori DO;Nalls MA;Nelson CP;Norris JM;O'Connell J;Ogunniyi A;Padmanabhan S;Palmer ND;Pedersen NL;Perls T;Peters A;Petersmann A;Peyser PA;Polasek O;Porteous DJ;Raffel LJ;Rice TK;Rotter JI;Rudan I;Rueda-Ochoa OL;Sabanayagam C;Salako BL;Schreiner PJ;Shikany JM;Sidney SS;Sims M;Sitlani CM;Smith JA;Starr JM;Strauch K;Swertz MA;Teumer A;Tham YC;Uitterlinden AG;Vaidya D;van der Ende MY;Waldenberger M;Wang L;Wang YX;Wei WB;Weir DR;Wen W;Yao J;Yu B;Yu C;Yuan JM;Zhao W;Zonderman AB;Becker DM;Bowden DW;Deary IJ;Dörr M;Esko T;Freedman BI;Froguel P;Gasparini P;Gieger C;Jonas JB;Kammerer CM;Kato N;Lakka TA;Leander K;Lehtimäki T;Lifelines Cohort Study;Magnusson PKE;Marques-Vidal P;Penninx BWJH;Samani NJ;van der Harst P;Wagenknecht LE;Wu T;Zheng W;Zhu X;Bouchard C;Cooper RS;Correa A;Evans MK;Gudnason V;Hayward C;Horta BL;Kelly TN;Kritchevsky SB;Levy D;Palmas WR;Pereira AC;Province MM;Psaty BM;Ridker PM;Rotimi CN;Tai ES;van Dam RM;van Duijn CM;Wong TY;Rice K;Gauderman WJ;Morrison AC;North KE;Kardia SLR;Caulfield MJ;Elliott P;Munroe PB;Franks PW;Rao DC;Fornage M
• 通讯作者: Fornage M