PILOT--QUANTITATIVE MRI ANALYSIS OF PSYCHOSIS IN ALZHEIMER'S DISEASE

精神病是老年痴呆症的常见行为并发症， 尤其是阿尔茨海默氏症(AD)。尽管有一定的边缘 结构被认为与认知和情感有关 慢性特发性精神病的异常，对此知之甚少 晚期精神病的神经病理学和神经放射学相关性 发病，包括与神经退行性疾病有关的疾病。 MRI提供了活体检测所需的解剖学分辨率 结构异常，比神经病理学有优势 该结果中的数据可能与同期临床相关 评估。 本研究的目的是使用计算机分析的MR来估计 伴和不伴AD患者特定脑结构的体积 精神病，试图确定一种可能的解剖学基础 迟发性精神病。对四组患者进行了分析。 (AD伴精神病、AD不伴精神病、路易躯体变异、对照)。 我们的假设是患有精神病的AD受试者会表现出 类似的结构异常与他们的精神病有关， 尤其累及豆状叶、额叶和内侧颞叶 结构。在阿尔茨海默病的路易体变体中，锥体外系 特点是临床表现的特点，累及 基底节结构预计会明显更多 很突出。 如果患者在研究期间死亡并进行尸检， 神经病理结果将与定量磁共振相关联。 分析。

Psychosis is a common behavioral complication of dementia in the elderly, and of Alzheimer's disease (AD) in particular. Although certain limbic structures have been implicated in the cognitive and emotional abnormalities of chronic idiopathic psychosis, little is known about the neuropathological and neuroradiological correlates of psychoses of later onset, including those associated with neurodegenerative disorders. MRI provides the anatomical resolution necessary for in vivo detection of structural abnormalities and has the advantage over neuropathologic data in that results may be correlated with concurrent clinical assessments. The aim of the present study is to use computer-analyzed MR to estimate volumes of specific cerebral structures in AD patients with and without psychosis in an attempt to identify a possible anatomical substrate of late-onset psychosis. Analysis is proposed on four groups of patients (AD with psychosis, AD without psychosis, Lewy body variant, controls). It is our hypothesis that AD subjects with psychosis will demonstrate similar structural abnormalities with regard to their psychosis, especially involving lenticular, frontal and mesial temporal lobe structures. In the Lewy body variant of AD, where extrapyramidal features are characteristic of the clinical presentation, involvement of basal ganglia structures would be expected to be significantly more prominent. If patients die and have autopsies during the time-frame of the study, neuropathological findings will be correlated with quantitative MR analysis.