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DETERMINE THE SAFETY AND TOLERABILITY OF PHENYLBUTYRATE IN HUNTINGTON'S DISEASE

DETERMINE THE SAFETY AND TOLERABILITY OF PHENYLBUTYRATE IN HUNTINGTON'S DISEASE
确定苯丁酸在亨廷顿病中的安全性和耐受性
批准号：
7606571
负责人：
JODY COREY-BLOOM
金额：
$1.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
项目状态：
已结题
起止时间：
2006-12-01 至 2007-11-30
来源：
https://reporter.nih.gov/project-details/7606571
关键词：
Computer Retrieval of Information on Scientific Projects DatabaseFundingGrantHuntington DiseaseIndividualInstitutionLabelMoodsMovementPhenylbutyratesPlacebosPsyche structureResearchResearch PersonnelResourcesSafetySourceSymptomsUnited States National Institutes of HealthWeekphenylbutyrate

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中文摘要
翻译
这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在HD患者中评价苯丁酸盐与安慰剂相比持续4周的安全性和耐受性，随后进行开放标签苯丁酸盐治疗;检查苯丁酸盐对HD症状（包括运动、情绪和精神功能）的影响。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To evaluate the safety and tolerability of phenylbutyrate as compared to placebo for four weeks followed by open-label phenylbutyrate in individuals with HD; to examine the effects of phenylbutyrate on HD symptoms including movement, mood and mental functioning.
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FRONTOSTRIATAL ACTIVATION IN SUBJECTS AT RISK FOR HUNTINGTON'S DISEASE
CLINICAL TRIAL: ACR16 VERSUS PLACEBO FOR THE SYMPTOMATIC TREATMENT OF HUNTINGTON
CLINICAL TRIAL: PHASE 3 STUDY OF DIMEBON IN PATIENTS WITH MILD-TO-MODERATE HUNTI
CLINICAL TRIAL: COOPERATIVE HUNTINGTON'S OBSERVATIONAL TRIAL (COHORT)
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