FRONTOSTRIATAL ACTIVATION IN SUBJECTS AT RISK FOR HUNTINGTON'S DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 通过在两个时间点扫描存在HD风险的受试者和对照组，使用功能和结构MRI检查存在HD风险的受试者在显著细胞丢失之前的脑部变化，以： 1)评估以下假设：与对照组相比，即使受试者距离明显疾病发作有多年时间，但有HD风险的受试者的额-纹状体回路功能激活异常。这将通过在时间点1比较风险HD受试者与对照来实现。 2)评估HD受试者额纹功能变化可以在相对较短的时间间隔内检测到的假设（大约）。12个月）通过在两个时间点扫描每个风险HD受试者和对照。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To use functional and structural MRI to examine brain changes in subjects at risk for HD prior to significant cell loss by scanning at risk HD subjects and controls at two time-points to: 1) evaluate the hypothesis that functional activation of fronto-striatal circuits is abnormal in subjects at risk for HD compared to controls even while subjects are many years away from manifest disease onset. This will be achieved by comparing at risk HD subjects to controls at timepoint 1. 2) evaluate the hypothesis that alterations in frontostriatal function in HD subjects are detectable over a comparatively short interval (approx. 12 months) by scanning each at risk HD subject and control at two time-points.