REACH TO GRASP IN THE DENTATE NUCLEUS

抓住齿状核

• 批准号: 2865566
• 负责人: MILTON P PONG
• 金额: $ 3.67万
• 依托单位: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2865566
• 关键词: behavior test; brain electrical activity; cats; dentate nucleus; dipeptides; electronic recording system; extracellular; histology; limb movement; microelectrodes; microinjections; neuroregulation; neurotransmitter antagonist; operant conditionings; psychomotor function; reticular formation; sensorimotor system

This research project aims to investigate a part of the neural control pathway for reach to grasp movements in cats. These movements are an essential part of many behaviors including feeding and defense. A reach to grasp movement was most likely utilized to pick up this document. When the movement fails, life changes drastically. To repair a deficit, an understanding of the basic neural control of the movement is necessary. The proposed research will contribute to this understanding. One of the fundamental aspects of the neural control of a movement is the organization of its control pathway in the nervous system. What areas of the brain control the movement? How do the control signals change as they progress through the brain? How is the control of the movement organized within the brain structures involved? Dr. Gibson's laboratory has concentrated on the control of the reach to grasp movement. His work has identified a pathway which appears dedicated to the control of the grasping aspect of the reach to grasp movement. This pathway includes the interpositus nucleus in the deep cerebellar nuclei and the magnocellular red nucleus. Neurons in these areas discharge sharply only to reach movements with a grasp. A grasp pathway suggests that there is a reach pathway. Recently, work in Dr. Gibson's laboratory has identified an area of the mesencephalic reticular formation where neurons discharge for reaching during the reach to grasp movement. Preliminary anatomical data from the lab suggests that the dentate nucleus projects to the reach related area of the mesencephalic reticular formation. The proposed research will first investigate the discharge from neurons in the dentate nucleus during reach to grasp movements. Next, the contribution these neural areas make to the reach to grasp will be studied through inactivation experiments of the dentate nucleus and the mesencephalic reticular formation. The deficits from the inactivation of each of the areas will be compared.

本研究项目旨在研究猫伸手抓握动作的部分神经控制通路。这些动作是许多行为的重要组成部分，包括进食和防御。抓握动作最有可能用来拿起这个文件。一旦运动失败，生活就会发生翻天覆地的变化。为了修复缺陷，了解运动的基本神经控制是必要的。拟议的研究将有助于这种理解。运动的神经控制的一个基本方面是其控制通路在神经系统中的组织。大脑的哪些区域控制运动？控制信号在大脑中传递时是如何变化的？运动的控制是如何在相关的大脑结构中组织起来的？吉布森博士的实验室专注于对伸手抓握动作的控制。他的工作已经确定了一条通路，似乎专门用于控制伸手抓握运动的抓握方面。该通路包括小脑深部核间位核和大细胞红核。这些区域的神经元只有在抓取动作时才会剧烈放电。抓住途径表明有到达途径。最近，在吉布森博士的实验室里，研究人员发现了中脑网状结构的一个区域，在这个区域里，在伸手抓握运动中，神经元会释放伸手的冲动。实验室的初步解剖数据表明，齿状核投射到中脑网状结构的相关区域。本研究将首先研究齿状核神经元在伸手抓握运动中的放电情况。接下来，我们将通过齿状核和中脑网状结构的失活实验来研究这些神经区域对抓握范围的贡献。将比较每个区域失活造成的缺陷。