Understanding the transmission of tuberculosis using Mycobacterium tuberculosis sequence data

使用结核分枝杆菌序列数据了解结核病的传播

基本信息

  • 批准号:
    MR/N010469/1
  • 负责人:
  • 金额:
    $ 45.34万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2016
  • 资助国家:
    英国
  • 起止时间:
    2016 至 无数据
  • 项目状态:
    已结题

项目摘要

Tuberculosis is an infectious disease that causes a high public health burden. The World Health Organisation estimates that there are nine million new cases and nearly two million deaths each year. Establishing who transmits to whom and where is fundamental to disease control. By comparing the genetic profiles of tuberculosis-causing bacteria within large population-based studies we can identify likely transmissions based on the similarity of the strains. Our work will focus initially on a district of Malawi where tuberculosis disease prevalence has been high, and data and tuberculosis samples from nearly 2500 patients have been collected over twenty years. The inferred genetic profiles will use a higher proportion of the genome than used previously, allowing more accurate reconstructions of transmission chains. Factors influencing transmissibility will then be assessed directly by looking at the patterns of data within each transmission chain. These factors may be genetic variations within the bacteria themselves, or differences in the human hosts, including age, sex, HIV infection and treatment, and contact patterns. We will attempt to confirm any insights into these factors using data collected and generated from other populations. Ultimately, an improved understanding of the genetic and other processes underlying transmissibility could lead to the development of improved control measures. These could include novel drug or vaccine targets, or identification of geographical or socially determined hotspots of transmission.
结核病是一种造成沉重公共卫生负担的传染病。世界卫生组织估计,每年有900万新病例,近200万人死亡。确定谁传播给谁和在哪里传播对疾病控制至关重要。通过在大规模人群研究中比较结核病致病菌的遗传图谱,我们可以根据菌株的相似性确定可能的传播。我们的工作将首先集中在马拉维的一个地区,那里的结核病患病率一直很高,并从近2500名患者的数据和结核病样本已收集了二十多年。推断的遗传图谱将使用比以前更高比例的基因组,从而可以更准确地重建传播链。然后,通过查看每个传播链内的数据模式,直接评估影响传播率的因素。这些因素可能是细菌本身的遗传变异,也可能是人类宿主的差异,包括年龄、性别、艾滋病毒感染和治疗以及接触模式。我们将尝试使用从其他人群收集和生成的数据来确认对这些因素的任何见解。最后,对遗传和其他潜在遗传过程的更好理解可能导致制定更好的控制措施。这些可能包括新的药物或疫苗靶点,或确定地理或社会确定的传播热点。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa.
  • DOI:
    10.1038/s41467-021-23422-3
  • 发表时间:
    2021-05-26
  • 期刊:
  • 影响因子:
    16.6
  • 作者:
    Benavente ED;Manko E;Phelan J;Campos M;Nolder D;Fernandez D;Velez-Tobon G;Castaño AT;Dombrowski JG;Marinho CRF;Aguiar ACC;Pereira DB;Sriprawat K;Nosten F;Moon R;Sutherland CJ;Campino S;Clark TG
  • 通讯作者:
    Clark TG
Feature weighted models to address lineage dependency in drug-resistance prediction from Mycobacterium tuberculosis genome sequences.
Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development.
  • DOI:
    10.1038/s41598-018-33767-3
  • 发表时间:
    2018-10-18
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Benavente ED;Oresegun DR;de Sessions PF;Walker EM;Roper C;Dombrowski JG;de Souza RM;Marinho CRF;Sutherland CJ;Hibberd ML;Mohareb F;Baker DA;Clark TG;Campino S
  • 通讯作者:
    Campino S
Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis.
  • DOI:
    10.1038/srep42225
  • 发表时间:
    2017-02-08
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Andreu N;Phelan J;de Sessions PF;Cliff JM;Clark TG;Hibberd ML
  • 通讯作者:
    Hibberd ML
Identification of two insecticide resistance markers in Ethiopian Anopheles stephensi mosquitoes using a multiplex amplicon sequencing assay.
  • DOI:
    10.1038/s41598-023-32336-7
  • 发表时间:
    2023-04-05
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Acford-Palmer, Holly;Phelan, Jody E.;Tadesse, Fitsum G.;Kristan, Mojca;Collins, Emma;Spadar, Anton;Walker, Thomas;Bousema, Teun;Messenger, Louisa A.;Clark, Taane G.;Campino, Susana
  • 通讯作者:
    Campino, Susana
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Taane Clark其他文献

Taane Clark的其他文献

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{{ truncateString('Taane Clark', 18)}}的其他基金

AI assisted genomic profiling for the personalisation of treatment and control of infections
人工智能辅助基因组分析,实现个性化治疗和感染控制
  • 批准号:
    MR/X005895/1
  • 财政年份:
    2022
  • 资助金额:
    $ 45.34万
  • 项目类别:
    Research Grant
Using whole genome sequencing to reveal malaria parasite genetic diversity and drug resistance in Vietnam
利用全基因组测序揭示越南疟原虫遗传多样性和耐药性
  • 批准号:
    MR/R026297/1
  • 财政年份:
    2020
  • 资助金额:
    $ 45.34万
  • 项目类别:
    Research Grant
Serological tools for COVID-19 control and vaccine roll-out in Southeast Asia
用于在东南亚控制 COVID-19 和疫苗推广的血清学工具
  • 批准号:
    MR/V036890/1
  • 财政年份:
    2020
  • 资助金额:
    $ 45.34万
  • 项目类别:
    Research Grant
A lung-oriented controlled human infection model using live BCG to evaluate tuberculosis immunopathogenicity and vaccine efficacy (TB-CHIM).
使用活卡介苗评估结核病免疫致病性和疫苗功效的肺导向受控人类感染模型(TB-CHIM)。
  • 批准号:
    MR/S03563X/1
  • 财政年份:
    2019
  • 资助金额:
    $ 45.34万
  • 项目类别:
    Research Grant
Using host-responses and pathogen genomics to improve diagnostics for tuberculosis in Bandung, Indonesia
利用宿主反应和病原体基因组学来改进印度尼西亚万隆的结核病诊断
  • 批准号:
    MR/S01988X/1
  • 财政年份:
    2019
  • 资助金额:
    $ 45.34万
  • 项目类别:
    Research Grant
Using genomics to trace Salmonella transmission and antimicrobial resistance (AMR) in the poultry and swine food chains in the Philippines
利用基因组学追踪菲律宾家禽和猪食物链中的沙门氏菌传播和抗菌素耐药性 (AMR)
  • 批准号:
    BB/R013063/1
  • 财政年份:
    2018
  • 资助金额:
    $ 45.34万
  • 项目类别:
    Research Grant
Using host-responses and pathogen genomics to improve diagnostics for tuberculosis in the Philippines
利用宿主反应和病原体基因组学改进菲律宾结核病的诊断
  • 批准号:
    MR/R025576/1
  • 财政年份:
    2018
  • 资助金额:
    $ 45.34万
  • 项目类别:
    Research Grant
Using whole genome sequencing to characterise drug resistant Mycobacterium tuberculosis in Thailand
使用全基因组测序来表征泰国的耐药结核分枝杆菌
  • 批准号:
    MR/R020973/1
  • 财政年份:
    2018
  • 资助金额:
    $ 45.34万
  • 项目类别:
    Research Grant
Zika: Zika virus surveillance in human and mosquito populations in Cape Verde
寨卡:佛得角人类和蚊子种群中的寨卡病毒监测
  • 批准号:
    MC_PC_15103
  • 财政年份:
    2016
  • 资助金额:
    $ 45.34万
  • 项目类别:
    Intramural
Geographic genetic profiling of human Plasmodium malaria
人类疟原虫疟疾的地理遗传图谱
  • 批准号:
    MR/M01360X/1
  • 财政年份:
    2015
  • 资助金额:
    $ 45.34万
  • 项目类别:
    Research Grant

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Transmission 特征值及其相关逆散射问题的研究
  • 批准号:
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了解并解决在高负担城市环境中获得结核病服务的地理障碍
  • 批准号:
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了解和预测高艾滋病毒负担背景下耐多药结核病治疗的随访损失
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通过考虑结核分枝杆菌的宿主内异质性,提高对结核病传播的理解:在艾滋病毒高流行环境中进行的基于人群的分子流行病学研究
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谁是极端阳性、文化阴性的人?
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Who are the Ultra-positive, culture-negative? Understanding the trajectories of individuals in Uganda with trace M. tuberculosis nucleic acid in sputum
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