PERINATAL VITAL SIGNS MONITOR

描述：（申请人摘要）产时胎儿监测的目的是 一个健康的神经系统完好的婴儿电子胎心 速率监测（EFM）被广泛使用，但尚未显示出导致 显著降低神经损伤或围产期 死亡事实上，它的使用已经与不希望的增加有关， 在过去三年中，剖腹产率从4.5%上升到20%以上 几十年很明显，提供灵敏和特异性的设备 神经功能损害的指征将大大改善临床 分娩和分娩中的病人管理。 我们打算建立这样一个设备：围产期生命体征监测仪（PVSM）。 该设备将使医生能够获得标准的胎儿心脏， 频率描记法与单胎胎儿脑电图（fEEG）结果一致， 创新的四极头皮电极。此外，该设备将提供 一种新的数字化脑缺血损伤定量指标 信号处理方法称为倒谱距离。 在第一阶段，我们打算开发原型PVSM和四极胎儿头皮 电极沿着必要的信号处理工具。设备和 算法将在我们的围产期实验动物模型中进行测试。 窒息我们的长期目标是制定和实施 临床级PVSM，导致两者的护理显著改善 母亲和婴儿。 拟议商业应用：不可用

DESCRIPTION: (Applicant's abstract) The goal of intrapartum fetal monitoring is the delivery of healthy, neurologically intact baby. Electronic fetal heart rate monitoring (EFM) is widely used, yet it has not been shown to result in a significant decrease in the incidence of neurological damage or perinatal death. In fact, its use has been associated with the undesired increase in the rate of Cesarean delivery from 4.5 percent to over 20 percent in the past three decades. It is clear that a device which provides sensitive and specific indication of neurological compromise would greatly improve the clinical management of patients in labor and delivery. We intend to build such a device: the Perinatal Vital signs Monitor (PVSM). This device will enable the physician to obtain both the standard fetal heart rate tracing was well as the fetal electroencephalogram (fEEG) from a single innovative quadrapolar scalp electrode. Additionally, the device will provide a quantitative indicator of cerebral ischemic injury utilizing a novel digital signal processing method call Cepstral Distance. In Phase I, we intend to develop the prototype PVSM and quadrapolar fetal scalp electrode along with the necessary signal processing tools. The device and algorithms will be tested in our experimental animal model of perinatal asphyxia. Our long-term goal is the development and implementation of the clinical grade PVSM, resulting in a significant improvement in the care of both mother and baby. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE