qEP Analysis of Comatose Patients: Mutal Synchronicity

描述（由申请人提供）：据估计，美国每年约有250，000 - 300，000人经历心肺骤停（CPA）。大约80%的复苏患者仍处于昏迷状态一段时间。尽管现代医疗保健努力，这些患者中的许多人不会醒来。 在这种情况下，照顾者面临着继续积极治疗或撤回生命支持的艰难选择。 在评估这些昏迷患者的整体临床表现时，诱发电位（EP）可以提供有关脑功能的有用辅助反馈。因此，我们提出了第一阶段的努力，发展定量EP（qEP）分析技术，昏迷患者的评价。具体来说，我们提出了相互同步（MS）作为一种方法，联合收割机方面的幅度和潜伏期分析到一个统一的衡量脑损伤。 我们的I期研究的目标是：1）基于先进的信号处理理论开发互同步性（MS），以客观地表征皮层和脑干电活动，2）在CPA后恢复期间对昏迷患者进行初步评估时测试MS。从长远来看，我们计划研究使用这项技术作为床边工具，用于监测CPA后昏迷的进展。

DESCRIPTION (provided by applicant): It is estimated that approximately 250,000-300,000 people experience cardiopulmonary arrest (CPA) each year in the United States. Approximately 80% of resuscitated patients remain in a coma for some time. Despite modern day healthcare efforts, many of these patients will not awaken. In such cases, caregivers are confronted with the difficult choice of continuing aggressive therapy or withdrawing life support. In evaluating the overall clinical picture of these comatose patients, Evoked Potentials (EP) may provide useful adjunct feedback on brain function. Thus we propose a Phase I effort to develop quantitative EP (qEP) analysis techniques for evaluation of comatose patients. Specifically, we propose Mutual Synchronicity (MS) as a method to combine aspects of amplitude and latency analysis into a unifying measure of brain injury. The goals of our Phase I study are 1) to develop Mutual Synchronicity (MS) based on advanced signal processing theory for objectively characterizing cortical and brainstem electrical activity, and 2) to test MS in a preliminary evaluation of comatose patients during post-CPA recovery. In the long-term, we plan to investigate the use of this technology as a bedside tool for monitoring the progression of coma after CPA.