NEW INSTRUMENT TO ASSESS ENERGY EXPENDITURE IN INFANTS

评估婴儿能量消耗的新工具

• 批准号: 2800292
• 负责人: PHILIP T DEMPSTER
• 金额: $ 9.15万
• 依托单位: LIFE MEASUREMENT INSTRUMENT
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-15 至 2000-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2800292
• 关键词: bioenergetics; biomedical equipment development; calorimetry; clinical biomedical equipment; mother /infant health care; noninvasive diagnosis; oxygen consumption; portable biomedical equipment; respiratory airflow measurement; respiratory gas analyzer

The specific aim of the proposed research is to demonstrate proof-of- concept for a new whole-body indirect calorimeter for the measurement of energy expenditure in infants. The measurement of energy expenditure in infants is important for a number of reasons, including determination of energy requirements in health and disease, the metabolic cost of growth, optimal environmental conditions, and response to different feeds. Due to the current difficulty in obtaining energy expenditure measurements in this population, values are commonly estimated from tables or regression equations. These estimates show considerable variability and are of limited value in metabolic studies. The proposed instrument will incorporate new technologies related to the key measurements required for indirect calorimetry: gas analysis and airflow control. Furthermore, the overall system design will lead to enhanced accuracy and stability of measurement. Should this development prove successful, the result will be a new indirect calorimeter for infants that meets the following criteria: (1) non-invasive, (2) accurate, (3) stable, (4) maintains normal environment (21% O2, 0.03% CO2), (5) easy to use, and (6) portable. The availability of such a product could significantly contribute to the study and care of infants under a variety of circumstances. PROPOSED COMMERCIAL APPLICATION: There are commercial applications in research and health care for the resultant whole-body indirect calorimeter; including the study of energy balance, growth, and enhanced nutritional requirements under certain conditions, e.g., in burn patients. The component technologies used in the system, specifically the methods of airflow measurement and oxygen analysis, are also commercially marketable technologies having both health care and industrial applications.

拟议研究的具体目的是证明一种新的全身间接量热计用于测量婴儿能量消耗的概念验证。衡量婴儿的能量消耗具有重要意义，原因有很多，包括确定健康和疾病的能量需求、生长的代谢成本、最佳环境条件以及对不同饲料的反应。由于目前在这一人群中很难获得能量消耗测量，因此通常从表格或回归方程中估计数值。这些估计显示出相当大的变异性，在新陈代谢研究中的价值有限。拟议的仪器将采用与间接量热法所需的关键测量相关的新技术：气体分析和气流控制。此外，整个系统的设计将提高测量的准确性和稳定性。如果这项开发被证明是成功的，结果将是一种新的间接热量计，它满足以下标准：(1)非侵入性，(2)准确，(3)稳定，(4)保持正常环境(21%O2，0.03%CO2)，(5)易于使用，(6)便携。在各种情况下，这种产品的提供可以大大促进对婴儿的研究和护理。拟议的商业应用：合成的全身间接量热计在研究和保健方面有商业应用；包括研究特定条件下的能量平衡、生长和增强的营养需求，例如在烧伤患者中。系统中使用的组件技术，特别是气流测量和氧气分析方法，也是具有医疗保健和工业应用的商业技术。