A NEW GENERATION METABOLIC ANALYSIS SYSTEM

新一代代谢分析系统

• 批准号: 6389622
• 负责人: PHILIP T DEMPSTER
• 金额: $ 28.6万
• 依托单位: LIFE MEASUREMENT INSTRUMENT
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6389622
• 关键词: basal metabolism; bioengineering /biomedical engineering; biomedical equipment development; biosensor device; breath composition; carbon dioxide; clinical biomedical equipment; clinical research; gas analyzer; human subject; magnetism; monitoring device; oxygen; pediatrics; respiratory gas analyzer; respiratory oxygen

The goal of this research is to develop a unique respiratory gas analyzer for both oxygen and carbon dioxide, characterized by very fast response, high stability, and significant cost savings. It incorporates new approaches to sensing O2 and CO2 not previously demonstrated in gas analysis. In Phase I, the applicant organization demonstrated proof-of- concept by building a prototype whose specifications currently exceed those of some commercially available gas analyzers costing three times as much. The technology also provides many practical advantages, e.g., the weight of the combined O2/CO2 analyzer is less than 2.5 kg, while competitive gas analyzers weight over 28 kg. Projected cost is approximately $5,000. Proposed Phase II research will improve the design, including extending the capability to pediatric and neonatal applications, and incorporate the resulting gas analyzer into a complete metabolic analysis system. Both bench testing and validation with human subjects will take place. This research will lead to a new technology useful and cost effective for patient monitoring, exercise stress testing, metabolic analysis, and monitoring of controlled atmospheres such as hyperbaric chambers. There are also industrial applications, including greenhouse monitoring, food processing, and pollution control. The applicant's organization has a successful track record in developing and commercializing SBIR technology. PROPOSED COMMERCIAL APPLICATION: Commercial applications include health-related applications such as patient monitoring, metabolic measurement, exercise stress testing, and nutritional evaluation. Other industrial applications include greenhouse monitoring, food processing, and other environmental monitoring. The resultant O2/CO2 gas analyzer will be marketed as a stand alone product and incorporated into a metabolic analysis system.

本研究的目标是开发一种独特的氧气和二氧化碳呼吸气体分析仪，具有响应速度快、稳定性高、节省大量成本的特点。它结合了以前在气体分析中没有展示的检测O2和CO2的新方法。在第一阶段，申请组织展示了概念验证，建造了一个原型，其规格目前超过了一些商业气体分析仪的三倍。该技术还提供了许多实用的优势，例如，O2/CO2组合分析仪的重量不到2.5公斤，而竞争对手的气体分析仪重量超过28公斤。预计费用约为5000美元。拟议的第二阶段研究将改进设计，包括将能力扩展到儿科和新生儿应用，并将产生的气体分析仪整合到完整的代谢分析系统中。将进行试验台测试和人体受试者验证。这项研究将带来一种新的技术，用于患者监测、运动负荷测试、代谢分析和高压舱等受控环境的监测，具有实用和成本效益。也有工业应用，包括温室监测、食品加工和污染控制。申请人的组织在开发和商业化SBIR技术方面有成功的记录。拟议的商业应用：商业应用包括与健康相关的应用，如患者监测、新陈代谢测量、运动压力测试和营养评估。其他工业应用包括温室监测、食品加工和其他环境监测。由此产生的O2/CO2气体分析仪将作为独立产品上市，并纳入代谢分析系统。