A NEW GENERATION METABOLIC ANALYSIS SYSTEM

新一代代谢分析系统

• 批准号: 6141378
• 负责人: PHILIP T DEMPSTER
• 金额: $ 38.61万
• 依托单位: LIFE MEASUREMENT INSTRUMENT
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6141378
• 关键词: basal metabolism; bioengineering /biomedical engineering; biomedical equipment development; biosensor device; breath composition; carbon dioxide; clinical biomedical equipment; clinical research; gas analyzer; human subject; magnetism; monitoring device; oxygen; pediatrics; respiratory gas analyzer; respiratory oxygen

The goal of this research is to develop a unique respiratory gas analyzer for both oxygen and carbon dioxide, characterized by very fast response, high stability, and significant cost savings. It incorporates new approaches to sensing O2 and CO2 not previously demonstrated in gas analysis. In Phase I, the applicant organization demonstrated proof-of- concept by building a prototype whose specifications currently exceed those of some commercially available gas analyzers costing three times as much. The technology also provides many practical advantages, e.g., the weight of the combined O2/CO2 analyzer is less than 2.5 kg, while competitive gas analyzers weight over 28 kg. Projected cost is approximately $5,000. Proposed Phase II research will improve the design, including extending the capability to pediatric and neonatal applications, and incorporate the resulting gas analyzer into a complete metabolic analysis system. Both bench testing and validation with human subjects will take place. This research will lead to a new technology useful and cost effective for patient monitoring, exercise stress testing, metabolic analysis, and monitoring of controlled atmospheres such as hyperbaric chambers. There are also industrial applications, including greenhouse monitoring, food processing, and pollution control. The applicant's organization has a successful track record in developing and commercializing SBIR technology. PROPOSED COMMERCIAL APPLICATION: Commercial applications include health-related applications such as patient monitoring, metabolic measurement, exercise stress testing, and nutritional evaluation. Other industrial applications include greenhouse monitoring, food processing, and other environmental monitoring. The resultant O2/CO2 gas analyzer will be marketed as a stand alone product and incorporated into a metabolic analysis system.

本研究的目标是开发一种独特的氧气和二氧化碳呼吸气体分析仪，其特点是响应速度快，稳定性高，成本显著降低。它结合了新的方法来传感O2和CO2以前没有证明在气体分析。在第一阶段，申请机构通过建立一个原型来展示概念验证，该原型的规格目前超过了一些商业上可用的气体分析仪，其成本是其三倍。该技术还提供了许多实用优势，例如，组合O2/CO2分析仪的重量小于2.5 kg，而竞争性气体分析仪的重量超过28 kg。预计费用约为5 000美元。拟议的II期研究将改进设计，包括将功能扩展到儿科和新生儿应用，并将产生的气体分析仪纳入完整的代谢分析系统。将进行台架测试和人类受试者验证。这项研究将为病人监测、运动压力测试、代谢分析和控制气氛监测（如高压氧舱）带来一种有用且经济有效的新技术。还有工业应用，包括温室监测、食品加工和污染控制。申请人的组织在开发和商业化SBIR技术方面有成功的记录。拟议的商业应用：商业应用包括与健康相关的应用，如患者监测、代谢测量、运动压力测试和营养评估。其他工业应用包括温室监测、食品加工和其他环境监测。由此产生的O2/CO2气体分析仪将作为一个独立的产品销售，并纳入代谢分析系统。