FAST DUAL PATH SYSTEM FOR RESPIRATORY GAS ANALYSIS

用于呼吸气体分析的快速双通道系统

• 批准号: 2030981
• 负责人: PHILIP T DEMPSTER
• 金额: $ 9.58万
• 依托单位: LIFE MEASUREMENT INSTRUMENT
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2030981
• 关键词: biomedical equipment development; biosensor device; breath composition; clinical biomedical equipment; magnetism; respiratory gas analyzer; respiratory oxygen

The goal of the proposed Phase I research is to determine the feasibility of a fast dual path system for respiratory gas analysis. Applications for respiratory gas analysis in health care and physiological assessment and numerous and important, including the measurement of metabolism, lung ventilation efficiency, and patient monitoring. This research proposes development of a system that incorporates a unique method of oxygen analysis based on paramagnetism coupled with an acoustic method to determine carbon dioxide for any given level of oxygen. Essential to the proposed research is development and implementation of high speed pneumatic switching to rapidly interchange test and ambient gas in each transducer (paramagnetic and acoustic), thus providing exceptional stability. The resulting Phase I prototype will be evaluated for dynamic response, linearity, stability of baseline, and stability of scale. It is anticipated that the resulting respiratory gas analyzer will have a response time of <75 ms, and will be capable of breath-by-breath analysis. The proposed development will lead to a new generation of respiratory gas analyzers exhibiting superior performance together with significant cost savings. The estimated cost of the final O2/CO2 analyzer is between $750 - $1,000. PROPOSED COMMERCIAL APPLICATION: Respiratory gas analysis is widespread in the health care environment and physiological research. Oxygen and carbon dioxide analyzers are commonly found as stand-alone analyzers or combined in metabolic measurement systems or anesthetic monitors. Thousands of respiratory gas analyzers are sold each year, and there has been little progress in the critical sensing technologies over the past few years. The commercial potential of the proposed development is significant primarily for the high level of performance coupled with significantly reduced cost.

拟议的第一阶段研究的目标是确定 呼吸气体分析的快速双通道系统。 应用 用于健康护理和生理评估中的呼吸气体分析 和众多的和重要的，包括测量代谢，肺 通风效率和患者监测。本研究提出 开发了一种系统，该系统采用了独特的供氧方法， 分析的基础上顺磁性耦合声学方法， 测定任何给定氧含量的二氧化碳。必不可少的 拟议的研究是开发和实施高速 气动切换，以快速交换测试气体和环境气体， 传感器（顺磁性和声学），从而提供卓越的 稳定 将对由此产生的第一阶段原型进行动态评估。 响应、线性、基线稳定性和标度稳定性。它 预计最终的呼吸气体分析仪将具有 响应时间<75 ms，并将能够进行逐呼吸 分析.拟议的发展将导致新一代的 具有上级性能的呼吸气体分析仪， 显著的成本节约。最终O2/CO2分析仪的估计成本 在750到1000美元之间。 拟议商业应用：呼吸气体分析广泛应用 在健康护理环境和生理研究中。氧和 二氧化碳分析仪通常作为独立的分析仪， 结合在代谢测量系统或麻醉监测器中。 每年销售数千台呼吸气体分析仪， 过去在关键的传感技术方面进展甚微 几年建议发展项目的商业潜力为 重要的主要是高水平的性能加上 大大降低了成本。