NOVEL CORROSION RESISTANT BIOACTIVE SURGICAL IMPLANTS

新型耐腐蚀生物活性手术植入物

• 批准号: 2870242
• 负责人: ZORAN S MINEVSKI
• 金额: $ 48.37万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2870242
• 关键词: biomechanics; biomedical equipment development; corrosions; electrochemistry; implant; medical implant science; orthopedics; phosphates; surface coating; titanium

DESCRIPTION (Adapted from the applicant's abstract): Phase I research demonstrated the technical feasibility for electrolytic phosphation of Ti6Al4V alloys. It was shown that surface phosphate concentration could be carefully controlled using deposition voltage, deposition time, temperature and concentration of H3PO4. Polarization tests for quantifying corrosion resistance showed that electrodes phosphated at 100V (high phosphate deposition) exhibited corrosion protection 46 times higher than the untreated control samples. Likewise, adhesion and wear tests all showed highly positive results when compared with controls. These comprehensive Phase I results confirmed the technical feasibility of the phosphate barrier and established the scientific basis for expanding the scope of Phase II experiments and tests to quantify this surface treatment of surgical alloys for medical applications. Phase II research will begin by applying this new surface treatment to specific implant devices followed by a series of in vitro and in vivo tests to evaluate pertinent orthopaedic implant parameters. Tests will be conducted to further expand our understanding of the electrochemical features of this barrier as well as bioactive attributes that will be assisted using recognized laboratory animal procedures. The benefits of the proposed phosphated surgical implants will be: (1) high corrosion resistance, (2) excellent mechanical properties, e.g. low friction, excellent antiwear properties and good adhesion and (3) similar or lower production costs due to minimal needs of the proposed procedure. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人的摘要）：第一阶段研究 论证了Ti6Al4V电解磷化的技术可行性 合金。结果表明，表面磷酸盐浓度可以仔细控制 使用沉积电压、沉积时间、温度和控制 H3PO4 的浓度。用于量化耐腐蚀性的极化测试 显示在 100V 磷酸盐化的电极（高磷酸盐沉积）表现出 防腐蚀能力比未经处理的对照样品高 46 倍。 同样，粘附力和磨损测试均显示出非常积极的结果 与对照相比。这些全面的第一阶段结果证实了 磷酸盐屏障的技术可行性并建立了科学的 扩大二期实验和测试范围的基础 这种用于医疗应用的外科合金的表面处理。 第二阶段研究将首先将这种新的表面处理应用于特定的 植入装置，然后进行一系列体外和体内测试来评估 相关骨科植入物参数。将进行测试以进一步 扩展我们对该势垒电化学特征的理解 以及生物活性属性，​​将使用公认的实验室来辅助 动物程序。拟议的磷酸盐手术植入物的优点 将：（1）高耐腐蚀性，（2）优异的机械性能， 例如低摩擦、优异的抗磨性能和良好的附着力和 (3) 由于拟议的最低需求，生产成本相似或更低 程序。 拟议的商业应用：不可用