NOVEL CORROSION RESISTANT BIOACTIVE SURGICAL IMPLANTS

新型耐腐蚀生物活性手术植入物

• 批准号: 6171575
• 负责人: ZORAN S MINEVSKI
• 金额: $ 25.39万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6171575
• 关键词: biomechanics; biomedical equipment development; corrosions; electrochemistry; implant; medical implant science; orthopedics; phosphates; surface coating; titanium

DESCRIPTION (Adapted from the applicant's abstract): Phase I research demonstrated the technical feasibility for electrolytic phosphation of Ti6Al4V alloys. It was shown that surface phosphate concentration could be carefully controlled using deposition voltage, deposition time, temperature and concentration of H3PO4. Polarization tests for quantifying corrosion resistance showed that electrodes phosphated at 100V (high phosphate deposition) exhibited corrosion protection 46 times higher than the untreated control samples. Likewise, adhesion and wear tests all showed highly positive results when compared with controls. These comprehensive Phase I results confirmed the technical feasibility of the phosphate barrier and established the scientific basis for expanding the scope of Phase II experiments and tests to quantify this surface treatment of surgical alloys for medical applications. Phase II research will begin by applying this new surface treatment to specific implant devices followed by a series of in vitro and in vivo tests to evaluate pertinent orthopaedic implant parameters. Tests will be conducted to further expand our understanding of the electrochemical features of this barrier as well as bioactive attributes that will be assisted using recognized laboratory animal procedures. The benefits of the proposed phosphated surgical implants will be: (1) high corrosion resistance, (2) excellent mechanical properties, e.g. low friction, excellent antiwear properties and good adhesion and (3) similar or lower production costs due to minimal needs of the proposed procedure. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人摘要）：第一阶段研究

项目成果

Effect of phosphate treatment of Acid-etched implants on mineral apposition rates near implants in a dog model.

酸蚀植入物的磷酸盐处理对狗模型中植入物附近矿物质沉积率的影响。

• 发表时间: 2010
• 期刊: The International journal of oral & maxillofacial implants
• 作者: Foley,ChristineHyon;Kerns,DavidG;Hallmon,WilliamW;Rivera-Hidalgo,Francisco;Nelson,CarlJ;Spears,Robert;Dechow,PaulC;Opperman,LynneA
• 通讯作者: Opperman,LynneA