Osseoinductive Surface Treatment for Dental Implants

牙种植体的骨诱导表面处理

• 批准号: 6935510
• 负责人: ZORAN S MINEVSKI
• 金额: $ 13.42万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6935510
• 关键词: alloys; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; cell adhesion; corrosions; cytotoxicity; electrochemistry; electrolytes; endosseous dental implant; hardness; medical implant science; phosphates; surface coating; surface property; titanium

DESCRIPTION (provided by applicant): Despite recent major advances in dental implants, too often they fail because of inadequate osseointegration of the device with bone. Establishing and maintaining mature bone at the bone/device interface is critical to the success of the prosthesis. Lynntech, Inc., through related research involving titanium hip implants, has developed an electrolytic phosphate surface treatment that offers improved surface hardness and corrosion resistance as well as significantly enhances implant contact with bone and marrow at the substrate. The proposed Phase I research outlines a plan to investigate the technical features and advantages of Lynntech's surface treatment when applied under the specific conditions associated with dental implants. The modified surface of the dental implants to be fabricated during Phase I research will be composed of a uniform and relatively thick layer of incorporated phosphate ions. Optimizing the phosphate content of this layer will be an important part of the research effort in order to improve osseointegration at the surface and thus implant fixation. Phase I research will entail applying this new surface treatment to specific surgical titanium alloys followed by a series of dynamic in vitro wear, corrosion, cellular toxicity and cell adhesion/viability tests to evaluate pertinent dental implant parameters. The proposed surface treatment has the potential to enhance implant contact with bone at the surface and decrease interface fibrous tissue which has relevance for the short and long-term fixation of titanium dental implants. Lynntech's novel technique of phosphating titanium alloys is ideally suited to meet the key technical requirements for becoming a new surface modification for dental implant devices with significant implications for patient benefits. The relatively low capital costs and environmentally friendly nature of the proposed method make it suitable for use even in small dental clinics. It is estimated that the U.S. dental implant market will be approximately $370 million in 2003 and is expected to increase at a rate of 12 % per year over the next three of years.

描述（由申请人提供）：尽管牙科种植体最近取得了重大进展，但由于设备与骨的骨融合不足，它们经常失败。在骨/装置界面处建立和维持成熟骨是假体成功的关键。Lynntech, Inc.通过涉及钛髋关节植入物的相关研究，已经开发出一种电解磷酸盐表面处理方法，该方法可以提高表面硬度和耐腐蚀性，并显着增强植入物与基底处骨髓和骨骼的接触。拟议的第一阶段研究概述了一项计划，以调查Lynntech的表面处理在与牙科种植体相关的特定条件下应用时的技术特点和优势。在第一阶段的研究中，将制作的牙科种植体的修饰表面将由一层均匀且相对较厚的掺入磷酸盐离子层组成。优化这一层的磷酸盐含量将是研究工作的重要组成部分，以改善表面的骨整合，从而实现种植体的固定。第一阶段的研究将需要将这种新的表面处理应用于特定的外科钛合金，随后进行一系列动态体外磨损、腐蚀、细胞毒性和细胞粘附/活力测试，以评估相关的牙科种植体参数。所提出的表面处理有可能增强种植体与骨表面的接触，减少界面纤维组织，这与钛牙种植体的短期和长期固定有关。