Epidemiological features, national burden of several HPV-related diseases and estimation of cost-effectiveness of HPV vaccines in Vietnam

越南几种HPV相关疾病的流行病学特征、国家负担以及HPV疫苗的成本效益评估

基本信息

项目摘要

This project is designed to collect the evidence that will be needed to support the introduction of the cancer-preventing vaccine HPV (Human Papillomavirus) into the national immunization program of Vietnam. HPV is the second vaccine that has been developed that can prevent cancer (the first being Hepatitis B vaccine which prevents liver cancer). HPV vaccine prevents HPV infection, which is responsible for almost all cases of cancer of the cervix in women. In Western countries cancer of the cervix is much less common than in developing countries, because the regular cervical screening (Pap smears) identifies and treats very early cases. HPV is very common in developing countries like Vietnam, and the cancers that it causes are usually detected late, leading to high mortality. HPV is also responsible for a variety of other cancers affecting both men and women, including penile cancer, anal cancer and throat cancer. The vaccine is used is most industrialized countries, and is given to girls, and in some countries to boys as well. It has been introduced into very few developing countries, because of its high price, and the lack of evidence about HPV infection and disease in those countries. Vietnam is a rapidly modernizing country, with a booming economy and a population that is becoming increasingly westernized. HPV is spread by unprotected sex, and rates of infection are very high among sex workers and men who have sex with men. This project will study the rate of HPV infection among young university students in north, south and central Vietnam to get a national perspective. We will also study two important high risk groups, sex workers and men who have sex with men in both the north and south. We will use the records of the cancer hospitals in Vietnam to estimate the proportion of the population who were affected by HPV associated cancer, and to understand better the ages affected and the outcome and treatment costs of cases. This will enable us to predict the effect of HPV vaccine introduction on the community and calculate the money that will be saved by the health system if those cancers are prevented. Finally we will develop, within Vietnam, the laboratory skills that are needed to study HPV disease, and especially to undertake a trial of HPV vaccines in Vietnam. The trial is not covered by this proposal, but we hope in future to do a trial that will help us to decide which is the simplest and therefore least expensive, way to introduce HPV vaccine into a developing country like Vietnam. The project will be undertaken jointly by five institutions. The three Vietnamese institutions (two in the north and one in the south) will be able to share their expertise in this area and also develop new skills with help from expert groups in London (London School of Hygiene and Tropical Medicine) and Australia (Murdoch Childrens Research Institute).
该项目旨在收集所需的证据,以支持将预防癌症的HPV疫苗(人乳头瘤病毒)引入越南的国家免疫规划。人类乳头瘤病毒是第二种可以预防癌症的疫苗(第一种是预防肝癌的乙型肝炎疫苗)。HPV疫苗可以预防HPV感染,这是导致几乎所有女性宫颈癌的原因。在西方国家,宫颈癌比在发展中国家少得多,因为定期的子宫颈检查(巴氏涂片检查)可以识别和治疗非常早期的病例。HPV在越南等发展中国家非常普遍,它引起的癌症通常很晚才被发现,导致高死亡率。HPV还会导致其他多种影响男性和女性的癌症,包括阴茎癌、肛门癌和喉癌。大多数工业化国家使用这种疫苗,给女孩接种,在一些国家也给男孩接种。由于其价格高昂,以及在这些国家缺乏关于人乳头瘤病毒感染和疾病的证据,它已被引入极少数发展中国家。越南是一个快速现代化的国家,经济蓬勃发展,人口日益西化。HPV通过无保护的性行为传播,在性工作者和男男性行为者中感染率非常高。该项目将研究越南北部、南部和中部年轻大学生的HPV感染率,以获得全国视角。我们还将研究两个重要的高风险群体,即北部和南部的性工作者和男男性行为者。我们将使用越南癌症医院的记录来估计受HPV相关癌症影响的人口比例,并更好地了解受影响的年龄以及病例的结果和治疗费用。这将使我们能够预测HPV疫苗引入对社区的影响,并计算如果预防这些癌症,卫生系统将节省的资金。最后,我们将在越南发展研究人乳头瘤病毒疾病所需的实验室技能,特别是在越南进行人乳头瘤病毒疫苗试验。该试验不包括在本提案中,但我们希望在未来进行一项试验,这将有助于我们决定哪种方法最简单,因此最便宜,将HPV疫苗引入越南这样的发展中国家。该项目将由五个机构联合进行。越南的三个机构(两个在北部,一个在南部)将能够分享他们在这一领域的专业知识,并在伦敦(伦敦卫生和热带医学学院)和澳大利亚(默多克儿童研究所)专家组的帮助下开发新的技能。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam.
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Edward Mulholland其他文献

Attitudes to Short-Term Staffing and Workforce Priorities of Community Users of Remote Aboriginal Community-Controlled Health Services: A Qualitative Study
偏远原住民社区控制的卫生服务社区用户对短期人员配备和劳动力优先事项的态度:定性研究
  • DOI:
    10.3390/ijerph21040482
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Zania Liddle;M. Fitts;Lisa Bourke;L. Murakami;Narelle Campbell;Deborah J. Russell;Supriya Mathew;Jason Bonson;Edward Mulholland;John S. Humphreys;Yuejen Zhao;J. Boffa;Mark Ramjan;Annie Tangey;Rosalie Schultz;J. Wakerman
  • 通讯作者:
    J. Wakerman

Edward Mulholland的其他文献

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{{ truncateString('Edward Mulholland', 18)}}的其他基金

Generating epidemiological, economic and attitudinal evidence to inform policy-making about HPV vaccine introduction in India and Ethiopia
生成流行病学、经济和态度证据,为印度和埃塞俄比亚引进 HPV 疫苗的决策提供信息
  • 批准号:
    MR/R021686/1
  • 财政年份:
    2018
  • 资助金额:
    $ 51.51万
  • 项目类别:
    Research Grant

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