TESTING OF A NEW SYSTEM FOR CIRCULATORY SUPPORT

测试新的循环支持系统

• 批准号: 2901219
• 负责人: THOMAS C ROBINSON
• 金额: $ 34.59万
• 依托单位: MISSION MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-10 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2901219
• 关键词: animal tissue; biomaterial compatibility; biomedical automation; biomedical equipment development; blood circulation; blood flow measurement; circulatory assist; clinical biomedical equipment; computer program /software; evaluation /testing; extracorporeal circulation; hemolysis; human tissue

DESCRIPTION (Adapted from applicant's abstract): The long-term objectives of this research are the development and widespread use of an automated, safer, and more effective pumping system for patient circulatory support. The benefits in health care include: substantially lower blood damage; reduced thrombus accumulation; longer pump life; inherent and accurate blood flow rate control; elimination of backflow; limited, safe blood pressure levels; and lower costs compared to centrifugal blood pumping systems. This system also provided significant control an safety advantages compared to peristaltic pumps. The specific aims of this proposed research are functional optimizations, further improvements in blood compatibility, and development and fabrication of a complete practical system. A technologically innovative pumping control algorithm will be refined and optimized to maximize flow accuracy and speed of response and increase the flow control range for blood pumps covering the entire pediatric and adult ranges of operation. This system will be extensively tested in vitro with bovine blood and subsequently with human blood. PROPOSED COMMERCIAL APPLICATION: Not available.

描述（改编自申请人摘要）：长期 本研究的目标是开发和广泛使用 一种自动化、更安全、更有效的泵送系统， 循环支持保健方面的好处包括： 降低血液损伤;减少血栓积聚;延长泵寿命; 固有和精确的血液流速控制;消除回流; 有限的，安全的血压水平;和更低的成本相比， 离心泵血系统。 该系统还提供 与蠕动泵相比，具有显著的控制和安全优势。 这项拟议研究的具体目标是功能性的 优化，进一步改善血液相容性，以及 开发和制造一个完整的实用系统。 一 技术创新的泵送控制算法将得到完善， 优化以最大限度地提高流量精度和响应速度， 血泵的流量控制范围覆盖整个儿科， 成人的操作范围。 这一系统将在 用牛血体外培养，随后用人血培养。 拟议的商业应用：不可用。