AUTOMATED BLOOD COMPONENT SEPARATION

自动血液成分分离

• 批准号: 2857886
• 负责人: THOMAS C ROBINSON
• 金额: $ 25.56万
• 依托单位: MISSION MEDICAL, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2857886
• 关键词: biomedical automation; biomedical equipment development; blood; blood preservation; cell sorting; centrifugation; clinical biomedical equipment; erythrocytes; human tissue; physical separation

The long-term objectives of this research are the development and widespread use of an automated, closed, sterile system for blood component separation and for red cell washing to achieve extended red cell storage. The benefits in health care are the much reduced time, labor, and costs necessary to manufacture blood components compared to current methods. The use of continuous centrifugation and unique methods for bag support and contents removal provide the potential for substantial technological innovation. The proposed research performs the development and testing of automated prototype systems that optimize the processes, designs, and components shown feasible in the Phase I project. Tests include bovine and human blood studies and comparisons to current methods. Evaluations and guidance come from blood bank experts and users. PROPOSED COMMERCIAL APPLICATION The system developed as a result of this research is capable of replacing current manual methods for blood component manufacture in blood banks and hospitals. Millions of such blood components are made yearly in the United States. This system has the potential for widespread use due to faster processing, reduced labor and lower costs. It is also expected to have additional cell washing capabilities such as the deglycerolization of thawed previously-frozen red cells.

这项研究的长期目标是开发和 广泛使用自动化的、封闭的、无菌的血液系统 成分分离和红细胞洗涤，以实现延长红 细胞储存 医疗保健的好处是大大减少了时间， 劳动力和制造血液成分所需的成本， 目前的方法。 采用连续离心和独特的 用于袋支撑和内容物移除的方法提供了以下可能性： 实质性的技术创新。 拟议的研究执行 开发和测试自动化原型系统， 在第一阶段中表明可行的工艺、设计和部件 项目 测试包括牛和人的血液研究和比较 目前的方法。 评估和指导来自血库 专家和用户。 建议的商业应用 作为这项研究的结果开发的系统能够 取代目前手工生产血液成分的方法， 血库和医院 数以百万计的血液成分被制造出来 每年在美国。 该系统有潜力 由于更快的处理、减少的劳动力和更低的成本而广泛使用。 它还有望具有额外的细胞洗涤能力， 如解冻的先前冷冻的红细胞的去甘油化。