NONINVASIVE BLOOD-GAS MONITOR FOR INFANTS TO ADULTS

适用于婴儿至成人的无创血气监测仪

• 批准号: 3501469
• 负责人: THOMAS C ROBINSON
• 金额: $ 5万
• 依托单位: RASOR ASSOCIATES
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1990-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3501469
• 关键词: acid base balance; biosensor device; carbon dioxide tension; clinical biomedical equipment; diagnosis quality /standard; electrodes; human subject; noninvasive diagnosis; oral mucosa; oxygen tension; patient monitoring device; respiratory gas analyzer

The proposed Phase I research is intended to evaluate and demonstrate the feasibility of making accurate noninvasive and continuous measurements of arterial blood gases (p02, pC02, and pH) in a single device, utilizing the oral mucosa as a unique and optimal site for these measurements. Innovative sensor features will be evaluated in vitro and with human volunteers. Advanced technology previously developed by RAI for the oral measurement of p02 will be applied to modify presently available pC02 and pH sensors to permit oral use and achieve high accuracy of arterial blood-gas measurements. A miniaturized sensor module containing sensors for all three blood gases will be designed incorporating this technology and fitting easily and inobtrusively into the mouth. This sensor module found in any other devices; in particular, measurement accuracies which essentially equal those of blood gas machines are anticipated. The proposed research will define these clinical advantages along with the suitability of this concept to various patient types and clinical uses. This system is expected ton be equally applicable to infant, pediatric, adult, and aged patients.

拟议的第一阶段研究旨在评估和 证明进行准确无创和 连续测量动脉血气（p02、pco2 和 pH） 在单个设备中，利用口腔粘膜作为独特且 这些测量的最佳地点。 创新的传感器功能 将在体外和人类志愿者中进行评估。 先进的 RAI 先前开发的用于口腔测量的技术 p02 将用于修改当前可用的 pCO2 和 pH 传感器允许口腔使用并实现动脉的高精度 血气测量。 小型化传感器模块包含 所有三种血气传感器的设计将结合 这项技术可以轻松、不引人注目地安装到 嘴。 在任何其他设备中都可以找到此传感器模块；在 特别是，测量精度基本上等于 预计将有数台血气机。 拟议的研究将 定义这些临床优势以及该药物的适用性 不同患者类型和临床用途的概念。 这个系统 预计同样适用于婴儿、儿童、成人、 和老年患者。