Developing low-cost cognitive tools for dementia assessment in low-to-middle income countries (LMICs)

开发用于中低收入国家（LMIC）痴呆症评估的低成本认知工具

• 批准号: MR/P024696/1
• 负责人: Kim Graham
• 金额: $ 60.77万
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP024696%2F1
• 关键词: Developing; low; cost; cognitive; tools

In 2013, there were 44.4 million people with dementia worldwide. By 2030, this number will likely increase to 75.6 million, and by 2050 to 135.5 million. A new case of dementia is diagnosed somewhere in the world every 4 seconds. Not surprisingly, the costs of this public health challenge are substantial (US$604 billion in 2010, 1% of total global GDP). Notably, 58% of individuals experiencing dementia are thought to live in low-to-middle-income countries (LMICs), underlining the high impact of dementia in those regions, where - relative to high income countries (HICs) - understanding of dementia is low, health and social care less well developed, and social exclusion high. By 2050, it is estimated that 71% of individuals with dementia worldwide will be living in LMICs; the social and financial burden of dementia, therefore, is increasingly being felt in countries with limited health infrastructure and support for affected individuals. Compounding this problem, less than 10% of individuals in LMICs receive a dementia diagnosis, or tailored medical guidance to help them and their families understand how the particular form of dementia they are experiencing may impact on their daily living. These issues additionally limit involvement of LMICs in global clinical trials where new drug therapies may be subsidized, and supportive care provided.Rapid action is needed if these problems are to be addressed. In particular, there is an urgent need for effective, low-cost cognitive assessment approaches which can aid diagnosis and be used in geographically- and culturally-diverse areas of the world. When complemented by provision of information about different forms of dementia, this can help families and healthcare professionals implement appropriate and tailored care for patients, and identify individuals who can be included in global clinical trials. To address this problem, the Foundation Award focuses on the development of new digital cognitive testing platforms, able to be provided in LMICs via tablets and smartphones. We will work with collaborators from other HIC and LMICs across the globe also interested in advancing cognitive assessment in LMICs, ensuring a bidirectional partnership with the needs of LMICs foremost. The development and pilot work to be undertaken as part of this project will underpin further grant applications focused on development of a common cognitive assessment platform able to be applied to enhance assessment and interventional approaches focused on reducing the significant worldwide burden of dementia.

2013年，全球有4440万痴呆症患者。到2030年，这一数字可能会增加到7560万，到2050年将增加到1.355亿。世界上每4秒钟就有一个新的痴呆症病例被诊断出来。毫不奇怪，这一公共卫生挑战的成本是巨大的（2010年为6040亿美元，占全球GDP总额的1%）。值得注意的是，58%患有痴呆症的人被认为生活在低收入到中等收入国家（LMIC），强调了痴呆症在这些地区的高影响，相对于高收入国家（HIC），对痴呆症的理解较低，健康和社会护理欠发达，社会排斥较高。据估计，到2050年，全球71%的痴呆症患者将生活在中低收入国家;因此，在卫生基础设施和对受影响个人的支持有限的国家，痴呆症的社会和经济负担越来越大。使这一问题更加复杂的是，在中低收入国家，只有不到10%的人接受了痴呆症诊断，或接受了量身定制的医疗指导，以帮助他们及其家人了解他们所经历的特定形式的痴呆症如何影响他们的日常生活。这些问题还限制了中低收入国家参与全球临床试验，而这些临床试验可能会为新药治疗提供补贴，并提供支持性护理。特别是，迫切需要有效的，低成本的认知评估方法，可以帮助诊断，并在世界上地理和文化多样的地区使用。当提供有关不同形式痴呆症的信息时，这可以帮助家庭和医疗保健专业人员为患者实施适当和量身定制的护理，并确定可以纳入全球临床试验的个人。为了解决这个问题，基金会奖专注于开发新的数字认知测试平台，能够通过平板电脑和智能手机在LMIC中提供。我们将与来自地球仪的其他HIC和LMIC的合作者合作，这些合作者也对推进LMIC的认知评估感兴趣，确保与LMIC的需求建立双向合作关系。作为该项目的一部分，开发和试点工作将支持进一步的赠款申请，重点是开发一个共同的认知评估平台，该平台能够用于加强评估和干预方法，重点是减少全球痴呆症的重大负担。