COOPERATIVE BREAST CANCER TISSUE RESOURCE (CBCTR)

描述：(申请人描述) 合作乳腺癌组织资源(CBCTR)代表了 拥有大型档案的四个机构之间的合作 福尔马林固定的乳腺癌标本数量。这四个地点，在 与NCI的合作协议创建了CBCTR作为一个组织 乳腺癌研究人员的资源。CBCTR最初是 构思为提供大量样本，特别是为最终的 预后标志物的研究。CBCTR已经招收了近9000名档案 乳腺癌标本及其临床和随访资料 每件案子的细节。这些材料以“虚拟银行”的形式存在，而实际的 保留在各个地点的标本，但有中央数据库跟踪 每个样本。该数据库装载在万维网上，并且可以 由调查人员搜查，以确定死亡人数和类型 可从该资源获得的材料。然后，调查人员可以向 组织标本的CBCTR。申请由一个专家小组审查 专家，研究评价小组，科学价值和由 CBCTR首席调查员可行性协调委员会， 在提供所要求的标本之前。 西北分部的Kaiser Permanente提供了2500多份标本 CBCTR正在重新申请资金，以继续其在这方面的努力 项目。这一高度集成和稳定的医疗保健系统代表着 对于这样的项目来说，这是一个理想的环境。它已经诊断出大量的 自1970年以来，乳腺癌已将所有此类标本存档，并已完成 所有患者的临床和随访资料。最后， 该组织致力于公共领域的研究，并寻求 在乳腺癌研究方面与其他人分享其资源。

DESCRIPTION: (Applicant's Description) The Cooperative Breast Cancer Tissue Resource (CBCTR) represents a collaboration between four institutions that possess archives with large numbers of formalin-fixed breast cancer specimens. These four sites, under Cooperative Agreements with the NCI, have created the CBCTR as a tissue resource for investigators of breast cancer. The CBCTR was originally conceived to provide large numbers of specimens particularly for definitive studies of prognostic markers. The CBCTR has enrolled nearly 9,000 archival breast cancer specimens together with clinical and follow-up information about each case. The material exists as a "virtual bank" with the actual specimens remaining at the individual sites but a Central Database tracking each specimen. The database is mounted on the World Wide Web and may be searched by investigators seeking to ascertain the number and type of material available from this resource. Investigators may then apply to the CBCTR for tissue specimens. Applications are reviewed by a panel of experts, the Research Evaluation Panel, for scientific merit and by the CBCTR Coordinating Committee of Principal Investigator's for feasibility, prior to providing the requested specimens. Kaiser Permanente, Northwest Division has provided over 2,500 specimens to the CBCTR and is reapplying for funding to continue its efforts in this project. This highly integrated and stable medical care system represents an ideal setting for such a project. It has diagnosed a large number of breast cancers since 1970, has archived all such specimens and has complete clinical and follow-up information in its files on all patients. Finally, this organization is committed to research in the public domain and seeks to share its resources with others in the pursuit of breast cancer research.