Cooperative Breast Cancer Tissue Resource

合作乳腺癌组织资源

• 批准号: 7479518
• 负责人: ANDREW George GLASS
• 金额: $ 5.02万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2007-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7479518
• 关键词: Biological Markers; Biomedical Research; Client; Clinical; Clinical Markers; Collection; Communities; Cooperative Breast Cancer Tissue Resource; Daily; Data; Data Sources; Development; Diagnosis; Diagnostic tests; Evaluation; Evaluation Research; Funding; Goals; Individual; Institution; Letters; Link; Malignant Neoplasms; Medical Records; Modification; National Cancer Institute; Operative Surgical Procedures; Oregon; Outcome; Paper; Paraffin; Pathologic; Patients; Principal Investigator; Procedures; Process; Prognostic Marker; Request for Applications; Research Personnel; Resources; Role; Site; Slide; Source; Specimen; Testing; Tissue Microarray; Tissue Sample; Tissues; U-Series Cooperative Agreements; United States; Update; Validation; Woman; Work; Workload; base; cancer diagnosis; design; malignant breast neoplasm; member; neoplasm registry; outcome forecast; programs; research study; response; success; tumor; usability

The Cooperative Breast Cancer Tissue Resource (CBCTR) is sponsored by the National Cancer Institute to provide acrchival, paraffin-fixed specimens for the study of molecular markers. Kaiser Permanente, Portland, Oregon (KPNW) has been an active member of this project since 1994 and seeks to continue in this role in the next funding period. The CBCTR has collected over 9000 specimens of breast cancer tissue and linked it to demographic, clinical and outcome variables from cancer registries and medical records. The pathological material can be supplied as sections of blocks from the initial surgery undergone by individual patients or as a Tissue Microarray that combines tissue cores from hundreds of specimens. Researchers may apply for this material to enable the testing and/or validation of candidate prognostic markers. An independent Research Evaluation Panel evaluates these requests for scientific merit and technical feasibility. The Coordinating Committee of the CBCTR, comprising the Principal Investigators of the four sites, reviews these requests for appropriateness for the Resource. Considerations include the likelihood of success, impact on workloads and effect on the continuing operation and usability of the Resource. KPNW has contributed over 2400 specimens and distributed hundreds of tissue samples in the process of filling requests from researchers in the community. In addition, KPNW investigators and staff have contributed to the development and modifications of the procedures used in daily operations, to papers and presentations about the CBCTR, to displays at scientific meetings and to publicity efforts in the scientific community. As the CBCTR approaches its goal of wider use of its specimens, particularly of the TMAs, KPNW stands ready to replenish the collection with more, previously unexamined specimens from our files.

乳腺癌组织合作资源 (CBCTR) 由国家癌症研究所赞助，旨在 提供用于分子标记研究的石蜡固定标本。凯撒永久医疗机构， 俄勒冈州波特兰 (KPNW) 自 1994 年以来一直是该项目的积极成员，并寻求继续 在下一个资助期间发挥这一作用。 CBCTR 收集了 9000 多个乳腺癌组织样本，并将其与人口统计、 来自癌症登记和医疗记录的临床和结果变量。病理材料可以是 以个体患者初次手术时的块状部分或组织形式提供 结合了数百个样本的组织核心的微阵列。研究人员可以申请该材料 能够测试和/或验证候选预后标志物。独立研究 评估小组评估这些请求的科学价值和技术可行性。协调者 由四个地点的主要调查员组成的 CBCTR 委员会审查这些请求 资源的适当性。考虑因素包括成功的可能性、对工作负载的影响 以及对资源的持续运行和可用性的影响。 KPNW 在此过程中贡献了 2400 多个样本并分发了数百个组织样本 满足社区研究人员的请求。此外，KPNW 调查人员和工作人员还 为日常运营中使用的程序、文件和文件的开发和修改做出了贡献 有关 CBCTR 的演示、在科学会议上展示以及在科学领域的宣传工作 社区。随着 CBCTR 实现更广泛使用其样本（特别是 TMA）的目标， KPNW 随时准备用我们档案中更多以前未经检查的标本来补充馆藏。